The San Francisco 49ers and Arizona Cardinals both won in Week 10, and are within a couple of games of first place in the NFC West. This week, they will face off with one another at the legendary Estadio Azteca in Mexico City, in a marquee Monday Night Football matchup. In our NFL betting picks for Monday Night Football, we break down 49ers vs Cardinals from Mexico.
49ers vs Cardinals Betting Pick
This game will be played at Estadio Azteca at 8:15 PM ET on Monday, November 21, 2022.
Why Bet The Under:
✅ San Francisco has the fifth best scoring defense in the NFL so far this year. They are allowing 18.1 points per game, and they should be able to get the better of a Cardinals offense that has been hit or miss throughout this season.
✅ The Cardinals are dealing with a quarterback injury situation coming into this contest. They were without Kyler Murray last week against the Rams, and had to start Colt McCoy. Murray’s status is still uncertain due to an ankle ailment, and whether or not he can play here will either mean a backup quarterback or an injured one for this game.
✅ The Niners have seen six of their first nine games of this season go under the total. A lot of that is a product of their defense, which we will see perform at a high level again in this game, en route to an under.
NFL
San Francisco 49ers
Arizona Cardinals
Team Stats
Passing
Offense/Defense
SF | Passing | ARI |
---|---|---|
336 | CMP | 347 |
491 | ATT | 506 |
68.4 | CMP% | 68.6 |
257.9 | YDS/GM | 212.5 |
9.3 | Y/A | 7.6 |
8.4 | NY/A | 6.7 |
12 | INT | 11 |
34 | SK | 33 |
Defense/Offense
SF | Passing | ARI |
---|---|---|
410 | CMP | 355 |
621 | ATT | 555 |
66.0 | CMP% | 64.0 |
214.2 | YDS/GM | 184.9 |
6.4 | Y/A | 6.2 |
5.4 | NY/A | 5.3 |
22 | INT | 12 |
48 | SK | 42 |
Rushing
Offense/Defense
SF | Rushing | ARI |
---|---|---|
17 | G | 17 |
499 | ATT | 521 |
2389 | YDS | 2434 |
140.5 | Y/G | 143.2 |
4.8 | Y/A | 4.7 |
27 | TD | 19 |
1.6 | TD/G | 1.1 |
Defense/Offense
SF | Rushing | ARI |
---|---|---|
17 | G | 17 |
369 | ATT | 471 |
1525 | YDS | 2365 |
89.7 | Y/G | 139.1 |
4.1 | Y/A | 5.0 |
10 | TD | 17 |
0.6 | TD/G | 1 |
Special Teams
Offense/Defense
SF | Special Teams | ARI |
---|---|---|
34 | Punts/Ret | 36 |
273 | Punt/Yds | 366 |
8.0 | Punt/Y/R | 10.2 |
20 | Kick Off/Ret | 6 |
437 | Kick Off/Yds | 133 |
21.9 | Kick Off/Y/rt | 22.2 |
Defense/Offense
SF | Special Teams | ARI |
---|---|---|
22 | Punts/Ret | 31 |
220 | Punt/Yds | 286 |
10.0 | Punt/Y/R | 9.2 |
32 | Kick Off/Ret | 18 |
746 | Kick Off/Yds | 382 |
23.3 | Kick Off/Y/rt | 21.2 |
Scoring
Offense/Defense
SF | Scoring | ARI |
---|---|---|
17 | G | 17 |
27 | RshTD | 19 |
33 | RecTD | 32 |
21 | FGM | 26 |
25 | FGA | 31 |
28.9 | Pts/G | 26.8 |
Defense/Offense
SF | Scoring | ARI |
---|---|---|
17 | G | 17 |
10 | RshTD | 17 |
20 | RecTD | 18 |
29 | FGM | 28 |
33 | FGA | 33 |
17.5 | Pts/G | 19.4 |
Team Advanced Defense
SF | Defense | ARI |
---|---|---|
18.0% | Bltz% | 22.5% |
5.4% | Hrry% | 7.3% |
10.0% | QB Hit% | 4.5% |
21.0% | QB Prss% | 17.1% |
Injuries
Name | Position | Injury | Status | Updated |
---|---|---|---|---|
Arik Armstead | DL | Ankle | Out | 11/21/22 |
Curtis Robinson | LB | Gameday Inactive | Out | 11/21/22 |
Emmanuel Moseley | CB | Knee | Out | 11/21/22 |
Jason Verrett | CB | Knee | Out | 11/21/22 |
Javon Kinlaw | DT | Knee | Out | 11/21/22 |
Jordan Matthews | TE | Leg/knee | Out | 11/21/22 |
Kalia Davis | DL | Undisclosed | Out | 11/21/22 |
Kemoko Turay | DL | Gameday Inactive | Out | 11/21/22 |
Maurice Hurst | DL | Bicep | Out | 11/21/22 |
Nick Zakelj | OL | Gameday Inactive | Out | 11/21/22 |
Samson Ebukam | DL | Achilles/quad | Out | 11/21/22 |
Trey Lance | QB | Ankle | Out | 11/21/22 |
Tyrion Davis-Price | RB | Gameday Inactive | Out | 11/21/22 |
Charvarius Ward | CB | Personal | Questionable | 11/19/22 |
Danny Gray | WR | Ankle | Probable | 11/19/22 |
Name | Position | Injury | Status | Updated |
---|---|---|---|---|
Antoine Wesley | WR | Hip | Out | 11/21/22 |
Antwaun Woods | DT | Undisclosed | Out | 11/21/22 |
Byron Murphy Jr. | CB | Back | Out | 11/21/22 |
Darrel Williams | RB | Hip | Out | 11/21/22 |
D.J. Humphries | OL | Back | Out | 11/21/22 |
Jesse Luketa | OLB | Gameday Inactive | Out | 11/21/22 |
Jonathan Ward | RB | Hamstring | Out | 11/21/22 |
Joshua Miles | OL | Undisclosed | Out | 11/21/22 |
Justin Pugh | OL | Knee (acl) | Out | 11/21/22 |
Kyler Murray | QB | Hamstring | Out | 11/21/22 |
Lachavious Simmons | OL | Undisclosed | Out | 11/21/22 |
Marquis Hayes | OL | Knee | Out | 11/21/22 |
Max Garcia | OL | Shoulder | Out | 11/21/22 |
Nick Vigil | ILB | Hamstring | Out | 11/21/22 |
Rashard Lawrence | DT | Shoulder | Out | 11/21/22 |
Rodney Hudson | OL | Knee | Out | 11/21/22 |
Tae Daley | S | Undisclosed | Out | 11/21/22 |
Victor Dimukeje | OLB | Gameday Inactive | Out | 11/21/22 |
Will Hernandez | OL | Pectoral | Out | 11/21/22 |
Zach Ertz | TE | Leg | Out | 11/21/22 |
Budda Baker | S | Ankle | Questionable | 11/19/22 |
Marquise Brown | WR | Foot | Questionable | 11/21/22 |
Matt Prater | K | Hip | Questionable | 11/19/22 |
Colt McCoy | QB | Leg | Probable | 11/19/22 |
DeAndre Hopkins | WR | Hamstring | Probable | 11/21/22 |
Markus Golden | OLB | Illness | Probable | 11/19/22 |
Betting Trends
SF | Betting Trends | ARI |
---|---|---|
OVERALL | OVERALL | |
2-1-0 | Win/Loss/Tie | 1-2-0 |
1-2-0 | ATS W/L/P | 1-2-0 |
25.33 | Avg Score | 24.67 |
24.67 | Avg Opp Score | 27.33 |
AWAY | HOME | |
2-1-0 | Win/Loss/Tie | 1-2-0 |
2-1-0 | ATS W/L/P | 2-1-0 |
27.33 | Avg Score | 26.67 |
19 | Avg Opp Score | 28.33 |
SF | Betting Trends | ARI |
---|---|---|
OVERALL | OVERALL | |
3-2-0 | Win/Loss/Tie | 2-3-0 |
2-3-0 | ATS W/L/P | 2-3-0 |
25.4 | Avg Score | 25 |
23.4 | Avg Opp Score | 27 |
AWAY | HOME | |
2-3-0 | Win/Loss/Tie | 1-4-0 |
2-3-0 | ATS W/L/P | 2-3-0 |
20.4 | Avg Score | 22.6 |
17.4 | Avg Opp Score | 29.8 |
SF | Betting Trends | ARI |
---|---|---|
OVERALL | OVERALL | |
5-5-0 | Win/Loss/Tie | 4-6-0 |
5-5-0 | ATS W/L/P | 5-5-0 |
21.5 | Avg Score | 23 |
18.3 | Avg Opp Score | 25.8 |
AWAY | HOME | |
5-5-0 | Win/Loss/Tie | 1-9-0 |
6-4-0 | ATS W/L/P | 2-8-0 |
19.9 | Avg Score | 21.3 |
17.8 | Avg Opp Score | 29.7 |
Head to Head
Teams Last 10
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San Francisco 49ers
The San Francisco 49ers come into Monday night having beaten the Los Angeles Chargers on Sunday Night Football in Week 10. The defense for the Niners was incredible in that game, holding the Chargers to just 16 points. But the question coming into this game is on the offensive side of the ball.
Even with a healthy Christian McCaffrey and Deebo Samuel, the 49ers struggled to get things going offensively until the second half against Los Angeles. While they still got the win, the Cardinals could prove to be a challenge for the Niners offense as well if they do not pick up their level of play.
Arizona Cardinals
The Arizona Cardinals beat the Los Angeles Rams on Sunday, but it was not pretty. Arizona had to use Colt McCoy as their quarterback in the place of the injured Kyler Murray. McCoy did enough to help the Cardinals beat a John Wolford lead Rams team. But the Cardinals will hope that Murray is available for a tough test against one of the best defenses in the NFL.
It is worth remembering that Murray suffered an ankle injury last year, and the Cardinals saw their season go off the edge of a cliff. For the Cardinals to prevent that at the end of this season, they need Murray to play. And they will need him to play better than he did in the second half of last season.