The New Orleans Saints and San Francisco 49ers will meet in Week 12 of the NFL season in Santa Clara. The Niners will host this game after a short prep week, but the question coming into this contest is whether or not the Saints can take advantage. In our NFL picks for Sunday afternoon, we break down Saints vs 49ers, in an NFC matchup that will have major implications for the Niners.
Saints vs 49ers Betting Pick
| ℹ️ The Pick: | Under 42 |
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This game will be played at Levi’s Stadium at 4:25 PM ET on Sunday, November 27, 2022.
Why Bet The Under:
✅ The defense of the 49ers will once again be the big story of this game. San Francisco is a top-10 scoring defense in the NFL this year, an they have been dominant on the defensive side of the ball at home.
✅ The Saints really struggled to run the ball last time out against the LA Rams, and that will only get worse against a stout 49ers defense on Sunday.
✅ San Francisco has seen the vast majority of its games go under the total this season. Through Week 10, the Niners went under the total in six of their first nine games. That will continue here on their home field.
New Orleans Saints
San Francisco 49ers
Team Stats
Passing
Rushing
Special Teams
Scoring
Team Advanced Defense
Betting Odds
Injuries
| Name | Position | Injury | Status | Updated |
|---|---|---|---|---|
| Albert Huggins | DT | Leg | Out | 11/26/22 |
| Chase Hansen | LB | Knee | Out | 11/26/22 |
| Deonte Harty | WR | Foot | Out | 11/26/22 |
| D'Marco Jackson | LB | Undisclosed | Out | 11/26/22 |
| Dylan Soehner | TE | Undisclosed | Out | 11/26/22 |
| Erik McCoy | OL | Calf | Out | 11/26/22 |
| Ethan Greenidge | OT | Knee | Out | 11/26/22 |
| Forrest Lamp | G | Undisclosed | Out | 11/26/22 |
| Isaiah Pryor | LB | Undisclosed | Out | 11/26/22 |
| J.T. Gray | DB | Hamstring | Out | 11/26/22 |
| Michael Thomas | WR | Foot | Out | 11/26/22 |
| Payton Turner | DE | Ankle | Out | 11/26/22 |
| Pete Werner | LB | Ankle | Out | 11/26/22 |
| Smoke Monday | S | Knee (acl) | Out | 11/26/22 |
| Alvin Kamara | RB | Illness | Questionable | 11/25/22 |
| Andrus Peat | OL | Triceps | Questionable | 11/26/22 |
| Bradley Roby | CB | Ankle | Questionable | 11/26/22 |
| Cameron Jordan | DE | Eye | Questionable | 11/26/22 |
| Jarvis Landry | WR | Ankle | Questionable | 11/25/22 |
| Marcus Davenport | DE | Calf | Questionable | 11/26/22 |
| Mark Ingram II | RB | Knee | Questionable | 11/26/22 |
| Marshon Lattimore | CB | Abdomen | Questionable | 11/26/22 |
| Trevor Penning | OT | Foot | Questionable | 11/26/22 |
| James Hurst | OL | Concussion | Probable | 11/25/22 |
| Ryan Ramczyk | OT | Back | Probable | 11/25/22 |
| Name | Position | Injury | Status | Updated |
|---|---|---|---|---|
| Emmanuel Moseley | CB | Knee | Out | 11/26/22 |
| Jason Verrett | CB | Knee | Out | 11/26/22 |
| Javon Kinlaw | DT | Knee | Out | 11/26/22 |
| Jordan Matthews | TE | Leg/knee | Out | 11/26/22 |
| Kalia Davis | DL | Undisclosed | Out | 11/26/22 |
| Maurice Hurst | DL | Bicep | Out | 11/26/22 |
| Trey Lance | QB | Ankle | Out | 11/26/22 |
| Arik Armstead | DL | Ankle/foot | Doubtful | 11/26/22 |
| Deebo Samuel | WR | Hamstring | Questionable | 11/26/22 |
| Samson Ebukam | DL | Achilles/quad | Questionable | 11/25/22 |
Betting Trends
| NO | Betting Trends | SF |
|---|---|---|
| OVERALL | OVERALL | |
| 1-2-0 | Win/Loss/Tie | 3-0-0 |
| 1-2-0 | ATS W/L/P | 2-1-0 |
| 16.67 | Avg Score | 30.33 |
| 22.33 | Avg Opp Score | 13.33 |
| AWAY | HOME | |
| 0-3-0 | Win/Loss/Tie | 2-1-0 |
| 0-3-0 | ATS W/L/P | 1-2-0 |
| 19.33 | Avg Score | 23 |
| 28 | Avg Opp Score | 23 |
| NO | Betting Trends | SF |
|---|---|---|
| OVERALL | OVERALL | |
| 2-3-0 | Win/Loss/Tie | 3-2-0 |
| 2-3-0 | ATS W/L/P | 2-3-0 |
| 21.6 | Avg Score | 25.6 |
| 21.8 | Avg Opp Score | 22.4 |
| AWAY | HOME | |
| 2-3-0 | Win/Loss/Tie | 4-1-0 |
| 1-4-0 | ATS W/L/P | 3-2-0 |
| 23 | Avg Score | 23.8 |
| 26 | Avg Opp Score | 16.6 |
| NO | Betting Trends | SF |
|---|---|---|
| OVERALL | OVERALL | |
| 3-7-0 | Win/Loss/Tie | 6-4-0 |
| 4-6-0 | ATS W/L/P | 5-5-0 |
| 22.2 | Avg Score | 23.6 |
| 24.1 | Avg Opp Score | 17.3 |
| AWAY | HOME | |
| 5-5-0 | Win/Loss/Tie | 7-3-0 |
| 4-6-0 | ATS W/L/P | 6-4-0 |
| 21.7 | Avg Score | 25 |
| 21.2 | Avg Opp Score | 19.3 |
Head to Head
Teams Last 10
Best Saints vs 49ers Sportsbook Promo
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New Orleans Saints
The New Orleans Saints come into this contest off of a win over the Los Angeles Rams at home. That was something of a revenge game, after the Saints lost to the Rams at home in the NFC Championship Game just a few seasons ago in controversial fashion. Here, the Saints play another familiar foe in recent playoff competition, and will aim to beat the 49ers in a similar fashion.
If the Saints are going to be the 49ers, they need to move the football on the ground effectively. San Francisco is one of the best defensive teams in the NFL against the pass. As a result, the run will be necessary to keep pressure off of Andy Dalton and the New Orleans passing attack.
San Francisco 49ers
The San Francisco 49ers are coming off of a Monday Night Football game, as they played the Arizona Cardinals in Mexico City on Monday night. Here, the Niners have to travel back from Mexico and get ready for a tough opponent on short rest. As has been the case for most of this season, the defense of the 49ers will be the key to this contest.
San Francisco ranks first in the NFL in total defense this season, which they will hope will lead to stops throughout this game against the Saints. While New Orleans has plenty of offensive weapons at the skill positions, the Niners have proven this season that skill position weapons are not too much for them to overcome.
