The Portland Trail Blazers head to Cleveland tonight to take on the Cleveland Cavaliers on Wednesday night. This is a clash that pits a young Blazers squad licking its wounds against a Cavs team seeking stability despite a ton of injuries. Here, I break down this inter-conference matchup in the NBA and provide you with my Trail Blazers vs Cavaliers prediction for Wednesday night’s game.
Our Trail Blazers vs Cavaliers Pick
Pick: Cleveland Cavaliers -9.5
Confidence: ★★★★☆
Game Snapshot
- Matchup: Portland Trail Blazers @ Cleveland Cavaliers
- Date & Time: Wednesday, December 3, 2025, 7:00 PM ET
- Venue: Rocket Arena, Cleveland, Ohio
- Broadcast: NBA League Pass
Trail Blazers vs Cavaliers Odds
| Spread | Moneyline | Total |
|---|---|---|
| CLE –9.5 | CLE –450 / POR +370 | 240.5 pts |
Key Storylines
- The Cavs are riding high after a big offensive night from Donovan Mitchell, who dropped 43 points in their most recent outing against the Indiana Pacers. His scoring touch remains a major threat to opposing defenses. Evan Mobley continues to anchor the paint for the Cavs providing rim protection and inside scoring that complement Cleveland’s backcourt firepower.
- Both Portland and Cleveland are dealing with depleted rosters. The Trail Blazers are missing the likes of Matisse Thubylle and Scoot Henderson, while Damian Lillard is out for the season. Cleveland is missing Max Strus, Jarrett Allen, Sam Merrill, and Larry Nance Jr. going into this contest.
- For Cleveland, consistency has been elusive this season. They’ve cycled through numerous lineups, with injuries preventing them from playing their typical starting five. Still, the Cavs are expected to get the job done against another banged up team here.
- This is the second game of a back-to-back for the Trail Blazers. They were defeated in Canada by the Toronto Raptors last night. Now the Blazers need to contend with the Cavs, as well as the quick turnaround of having to come back into the United States to play this game.
Head-to-Head & Betting Trends
- This is the first of two games these teams will play against each other this season.
- Portland is 11-10 against the spread this season.
- Cleveland is 7-15 against the spread going into this contest.
- The Trail Blazers have gone over the total in 14 of their first 21 games.
- Cleveland games have stayed under their totals 12 times in 22 games.
Best Player Props to Watch
| Player | Prop |
|---|---|
| Donovan Mitchell | Over 28.5 points |
| Evan Mobley | Over 10.5 rebounds |
| Shaedon Sharpe | Under 19.5 points |
Trail Blazers vs Cavaliers Model Projection
Score Projection: Portland 108 – Cleveland 122
Win Probability: Portland 28%, Cleveland 72%
Final Thoughts
Both of these teams are depleted from a health standpoint going into this game. But the Cavs do have a rest advantage going into this matchup thanks to the Blazers playing last night. I think that will help the Cavs win this game convincingly on Wednesday night and I am going to lay the points with Portland in what should be an interesting matchup between two teams trying to figure things out in spite of a ton of adversity.
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