Indiana Hoosiers vs Ohio State Buckeyes Prediction - 12/6/2025
Updated December 2, 2025
Updated December 2, 2025
The main event of conference championship weekend in college football will take place when the Indiana Hoosiers (12‑0) square off against the Ohio State Buckeyes (12‑0). Both teams arrive unbeaten, both with national championship hopes, and both with Heisman Trophy-quality quarterbacks. The winner of this game will go into the College Football Playoff as the top seed. Before number one and number two battle for the Big Ten title, you will find my Indiana vs Ohio State prediction below.
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Spread | Moneyline | Total | |
|---|---|---|---|
Indiana Hoosiers | +4.5 | +170 | Over 48.5 |
Ohio State Buckeyes | -4.5 | -205 | Under 48.5 |
Score Projection: Indiana 27 – Ohio State 30
Win Probability: Indiana 34%, Ohio State 66%
This is the game of the year in college football so far and I think we are going to get an instant classic in Indianapolis. I think that Indiana will look better offensively than anyone else has against the Ohio State defense this season. But I think that Ohio State will win with a late field goal. My best bet for the game is for Indiana to cover the number as an underdog, in what could be a preview of the national championship game in just over a month.
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