The Denver Nuggets will face the Indiana Pacers on Wednesday night in Indianapolis. With Denver sporting a 14‑6 record and Indy languishing at 4‑17, the Nuggets enter as heavy favorites. But recent injuries and for Denver could help to make this a more competitive game against a Pacers team that is desperate for wins at this stage of the year. Before tip-off from Gainbridge Fieldhouse, continue reading to get my Nuggets vs Pacers prediction for Wednesday night.
Our Nuggets vs Pacers Pick
Pick: Denver Nuggets -7.5
Confidence: ★★★★☆
Game Snapshot
- Matchup: Denver Nuggets @ Indiana Pacers
- Date & Time: Wednesday, December 3, 2025, 7:00 p.m. ET
- Venue: Gainbridge Fieldhouse, Indianapolis, Indiana
- Broadcast: NBA League Pass
Nuggets vs Pacers Odds
| Spread | Moneyline | Total |
|---|---|---|
| Nuggets –7.5 | DEN –310 / IND +250 | 235.5 |
Key Storylines
- Nuggets’ injuries creeping up. In their most recent game, Jamal Murray sprained his right ankle and did not return for the fourth quarter. That contest ended in a loss to the Dallas Mavericks, marking Denver’s fourth straight defeat at home. Murray is averaging a strong 23.3 points, 6.7 assists, and 4.5 rebounds this season. If he misses this game, or is limited, Denver’s backcourt production will take a sizeable hit. Meanwhile, the Nuggets are already operating without Aaron Gordon and Christian Braun. Nikola Jokic is also listed as questionable for this game.
- Pacers’ desperation and recent form. The Pacers have struggled mightily this season, but they may view this as a winnable game at home. After a loss to the Cleveland Cavaliers, in which they allowed 135 points, there will be motivation to tighten things up defensively. The Pacers remain without key contributors from last season, including Tyrese Haliburton and have suffered additional absences. Their leading scorer is Pascal Siakam, who averages 24.1 points, while Andrew Nembhard contributes 17.5 points and 6.2 assists per game. A strong home crowd and some defensive focus could make them at least competitive here.
- Tempo, shooting efficiency, and pace. Denver ranks at the top of the league offensively, putting up 124.6 points per game while shooting 50.9% from the field. They get good ball movement and efficient looks, especially from their starters. Indiana has been among the worst in the league in scoring (110.2 points/game) and three‑point shooting. If the Pacers can’t hit outside shots, they’ll struggle to keep up with Denver’s offense.
Head-to-Head & Betting Trends
- Denver defeated the Pacers 117-100 in the Mile High City earlier this season.
- Against the spread this season, Denver is 12–8 and the Pacers are 11–10.
- Denver has gone over the total 13 times in 20 games. The Pacers have stayed under the total 13 times in their 21 outings.
Best Player Props to Watch
| Player | Prop to Watch |
|---|---|
| Pascal Siakam | Over 22.5 Points |
| Jarace Walker | Over 8.5 Points |
| Nikola Jokic | Triple-Double |
Nuggets vs Pacers Model Projection
Score Projection: Denver 124 – Indiana 110
Win Probability: Denver 78%, Indiana 22%
Final Thoughts
The injury report for the Nuggets is concerning going into this game. But they should still be able to win and cover the spread on the road against the Pacers. As long as Jokic plays, the Pacers won’t have a defensive answer for the Nuggets’ offense. I’ll lay the points with the Nuggets going into Wednesday night’s game.
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