The ACC/SEC Challenge will continue on Wednesday night as the Clemson Tigers (7-1) hit the road to take on the Alabama Crimson Tide (5-2). Both teams come into this game on their own winning streaks and will try to extend those streaks here. I’ve broken this contest down from all angles and you will find my Clemson vs Alabama prediction right here.
Our Clemson vs Alabama Pick
- Pick: Alabama -10.5
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Clemson Tigers @ Alabama Crimson Tide
- Date & Time: Wednesday, December 3, 2025, 7:15 PM ET
- Venue: Coleman Coliseum, Tuscaloosa, AL
- Broadcast: ESPNU
Clemson vs Alabama Odds
| Spread | Moneyline | Total |
|---|---|---|
| Alabama -10.5 | Clemson +455 / Alabama -625 | O/U 166.5 |
Key Storylines
- Clemson’s growth and depth: The Tigers arrive with a 7-1 record, riding a four-game winning streak. They most recently earned a 92–56 blowout win over Alabama A&M. Transfer guard Jestin Porter has begun to settle in, posting 14 points in that win and averaging 11.0 PPG. Forward Carter Welling leads the team with 11.6 PPG and is joined by RJ Godfrey (11.3 PPG, 6.8 RPG), providing a balanced inside-outside threat. But this will be the biggest test of the young season so far for Clemson as they take on the high-octane offense of the Tide.
- Alabama’s firepower, but lingering injury concerns: The Crimson Tide are playing at home with motivation to bounce back after earlier losses to marquee opponents like Purdue and Gonzaga. They finished their trip to Las Vegas with two straight wins, including a 105–72 rout of Maryland. Nate Oats’ team will lean heavily on senior guard Labaron Philon Jr., who leads Alabama with 20.6 PPG and 5.7 assists per game. However, injuries to guard Jalil Bethea (foot) and forward Keitenn Bristow (leg), plus the absence of senior guard Latrell Wrightsell Jr., could impact them negatively against a power conference opponent.
- ACC vs. SEC bragging rights: This game is part of the SEC/ACC Challenge, and for Clemson, it’s a chance to prove its early-season record isn’t all smoke and mirrors. For Alabama, it’s a chance to reestablish dominance at home and send a message to the rest of the SEC and ACC.
Head-to-Head & Betting Trends
- The all-time series between the Tigers and Crimson Tide stands at 8–5 in favor of Clemson.
- Under current head coach Brad Brownell, Clemson is 2–2 vs Alabama.
- Alabama eliminated Clemson in the 2024 NCAA Tournament Elite Eight by a score of 89-82.
- Alabama is 3-3 against the spread for the season.
- Clemson is 4-3 against the spread going into Wednesday night.
Clemson vs Alabama Model Projection
Score Projection: Clemson 70 – Alabama 84
Win Probability: Clemson 28%, Alabama 72%
Final Thoughts
I will lay the points with Alabama on their home floor in this contest. Clemson’s non-conference strength of schedule is in the bottom 25 in the country going into this game, according to KenPom. In Tuscaloosa against one of the best teams in college basketball, I expect the Tigers to be brought down a peg here and for Alabama to win by double-digits.
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