In a game that was expected to be a Super Bowl preview going into this season, the San Francisco 49ers will visit the Buffalo Bills on Sunday Night Football in Week 13. Buffalo has held up its end of the bargain so far this season, but the Niners have struggled mightily and are in danger of missing the playoffs entirely. Here, we give you our NFL betting predictions for 49ers vs Bills, a game in which the Bills are favored by 5.5 points.
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49ers Dealing With Major Injury Concerns
The San Francisco 49ers have dropped two games in a row coming into Sunday night’s 49ers vs Bills matchup from Orchard Park, NY. That has dropped them to the bottom of the NFC West standings and has made their recent injury woes all the more difficult to deal with. After Brock Purdy and Nick Bosa missed the team’s Week 12 loss to the Green Bay Packers, the status of both of those key players will be make-or-break for San Francisco going into this game.
Bills Coming Off Their Bye
Going into Week 13, the Buffalo Bills have won six games in a row and they are in first place in the AFC East. They had their bye in Week 12, which means they should come into this 49ers vs Bills contest the fresher team. Buffalo is a perfect 5-0 at home so far this year and they will feel a ton of confidence going into this game after their last outing saw them hand the Kansas City Chiefs their first loss of the 2024 season.
49ers vs Bills Pick & Prediction
We will lay the points with the Buffalo Bills going into this 49ers vs Bills clash from Highmark Stadium. Buffalo is playing some of the best football in the NFL of late, with only the Detroit Lions and Philadelphia Eagles enjoying a similar level of performance of late. Against a banged-up Niners team on both sides of the ball, look for the Bills to win their seventh game in a row and for them to make yet another statement in front of their home crowd.
