The San Francisco 49ers travel to Cleveland to face the Cleveland Browns on Sunday in a tricky road test against a good defense. With chilly, rainy, and possibly snowy weather expected, we could be in for a defensive struggle. Can Shedeur Sanders improve to 2-0 as a starting quarterback in the NFL? Continue reading to get my 49ers vs Browns prediction for Week 13.
Our 49ers vs Browns Pick
Pick: Under 34.5
Confidence: ★★★★☆
Game Snapshot
- Matchup: San Francisco 49ers @ Cleveland Browns
- Date & Time: Sunday, November 30, 2025, 1:00 PM ET
- Venue: Huntington Bank Field, Cleveland, OH
- Broadcast: CBS
49ers vs Browns Odds
| Spread | Moneyline | Total |
|---|---|---|
| 49ers –5.5 | 49ers –240, Browns +200 | 34.5 points |
Key Storylines
- Weather may steal the show. Forecasts call for rain turning into snow, with 25–35 mph winds, and gusts potentially higher than that. Passing could be impaired on both sides, ball security will be harder, and special teams and field position could decide things.
- The Browns’ new energy. Rookie QB Shedeur Sanders gets his first home start in this game. He’s already shown flashes of brilliance with some good deep throws and a touchdown last week. The Browns will hope for a repeat performance here after Sanders won his first start against the Raiders last week.
- Pressure on Brock Purdy to deliver for the 49ers. Purdy has struggled in bad weather previously. He’s coming off a three-interception outing, and shaky throws in rain or snow could cost San Francisco dearly. Add a pass rush featuring Myles Garrett on the other side of this game, and the 49ers’ offense is facing a major test.
- Can the 49ers run it if the pass is broken? Star running back Christian McCaffrey didn’t practice this week, resting ahead of a tough stretch. He’s still expected to play. In sloppy weather, his abilities as runner and receiver could be key for sustaining drives and controlling this game.
Quarterback Play
Brock Purdy has looked efficient at times this season, but his recent turnovers are a concern. Wet conditions historically bring down his completion rate and passer rating significantly. If Purdy struggles, the 49ers’ offense could struggle to do enough to win this game.
On the other side, Shedeur Sanders is still early in his career, but last week’s win sparked optimism. He completed 11 of 20 passes for 209 yards, a touchdown, and an interception. He wasn’t efficient, but his deep throws were promising.
Betting Trends
- The 49ers are 7-5 against the spread so far this season.
- Cleveland is 5-6 against the spread this year.
- The Niners are 7-4-1 to the over heading into this matchup.
- The over has cashed in 6 of the Browns’ first 11 games.
49ers vs Browns Model Projection
Score Projection: 49ers 13 – Browns 10
Win Probability: 49ers 65%, Browns 35%
Final Thoughts
The weather should make this a low-scoring game in Cleveland. My best bet for this contest is for the under to hit, as we should see the Browns’ pass rush disrupt the Niners, while Shedeur Sanders continues to go through growing pains.
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