As Week 6 of the 2025 UFL season approaches, the DC Defenders are set to face the Michigan Panthers on Sunday, May 4, at Ford Field in Detroit. Both teams are vying for playoff positions, making this game crucial for their postseason aspirations. Continue reading to get our best bet for the DC Defenders vs Michigan Panthers matchup on Sunday.
DC Defenders vs Michigan Panthers Game Preview
The DC Defenders enter this matchup with a 4-1 record, as they enter this game in sole possession of the league’s best record through Week 5. Quarterback Jordan Ta’amu leads the league in passing yards, and he had a big game in DC’s 37-33 win over the Arlington Renegades last week. DC is 2-0 on the road so far this season and they will look to stay unbeaten on the road after this game in another big test for them.
On the other side, the Michigan Panthers boast a 3-2 record, coming off a loss to the St. Louis Battlehawks on the road. Michigan’s offense has been just as productive as that of DC so far this season, scoring one fewer point through the first half of the season. These teams are evenly matched in both points for and against on the year, but DC has been better at finishing games so far this season, which could come into play in this game.
Betting Insights
For the latest betting odds, we look at Sportzino ahead of this matchup.
- Point Spread: The Panthers are slight favorites, with the line favoring them by 3 points.
- Over/Under: The total points line is set at 42.5, reflecting expectations of a moderately high-scoring game.
- Moneyline: The Panthers are priced at -159 to win this game, while the Defenders are at +115, indicating a closely contested matchup.
Both of these teams were involved in high-scoring games last week, which could make the over a tempting bet in this contest. The Panthers lost 32-27 to the Battlehawks, while the Defenders won 37-33 over the Renegades. But we could see both defenses step up in response to their poor showings last week, while the potential for offensive regression is also a factor.
DC Defenders vs Michigan Panthers Prediction

Panthers -3 (-110) over Defenders
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- Michigan is 2-1 at home so far this season.
- We expect the Panthers defense to rebound from their struggles against the Battlehawks last week.
Considering the current form and statistical performance, the Michigan Panthers appear to have a slight edge in this contest. Their strong defense and home-field advantage positions them well against the Defenders. While DC’s high-powered offense cannot be overlooked, the Panthers should get the job done at home.
- Prediction: Michigan Panthers to win 24-20.
- Best Bet: Panthers -3
- Over/Under: Over 42.5 points.