The Arizona Cardinals will visit the Tampa Bay Buccaneers this Sunday in a key NFC showdown that could influence the playoff picture. Arizona has a 3‑8 record and their playoff hopes are basically gone, while Tampa Bay (6‑5) aims to end a losing streak and get back on track in their hunt for the postseason. Find out which team I think will win this game as I make my Cardinals vs Buccaneers prediction before kickoff on Sunday.
Our Cardinals vs Buccaneers Pick
- Pick: Buccaneers –3.5
- Confidence: ★★☆☆☆
Game Snapshot
- Matchup: Arizona Cardinals @ Tampa Bay Buccaneers
- Date & Time: Sunday, November 30, 2025, 1:00 PM Eastern
- Venue: Raymond James Stadium, Tampa, FL
- Broadcast: FOX
Cardinals vs Buccaneers Odds
| Spread | Moneyline | Total |
|---|---|---|
| TB –3.5 | TB –190, ARI +160 | 44.5 |
Key Storylines
- The Buccaneers enter a critical three‑game home stretch starting this week. They are at the top of the NFC South standings entering Week 13, but they have lost three games in a row. Their offense has struggled in recent games and the defense has yielded too many big plays. A bounce‑back performance is essential against a weaker opponent.
- The Cardinals are in free fall, having lost eight of their past nine games. Still, their passing attack under Jacoby Brissett has at least shown flashes after Kyler Murray went down due to injury.
- Injuries are impacting both sides entering this week. For Tampa Bay, Baker Mayfield is dealing with a sprained AC joint in his non‑throwing shoulder after exiting last week’s game early. He practiced Friday and is trending toward playing, but his mobility and comfort remain uncertain. Murray is out for Arizona, who is also missing some members of their offensive line.
Quarterback Play
Baker Mayfield has passed for 2,406 yards, 18 touchdowns, and five interceptions this season. He’s expected to start despite his shoulder issue. He has a history of playing through pain, but in a tight game, his effectiveness could be a key question mark.
Jacoby Brissett has become the focal point of Arizona’s offense. Brissett has gone for at least 258 yards in every start, including three games over 300 yards. Given Tampa Bay’s middling pass defense, Brissett could rack up big yardage again this week.
Betting Trends
- Both teams are 5-6 against the spread going into this matchup.
- The Cardinals are 7-4 to the over going into Week 13.
- The Bucs have gone over the total in 6 of their first 11 games.
Cardinals vs Buccaneers Model Projection
Score Projection: Tampa Bay 24 – Arizona 17
Win Probability: Tampa Bay 63%, Arizona 37%
Final Thoughts
Tampa Bay is in a great place to bounce back and end their losing streak in this game. The Bucs’ losing streak came in games against quality competition in the Bills, Rams, and Patriots. Against a team with a losing record, Tampa Bay should regain the upper hand. I’m going to lay the points with the Buccaneers, as they should get a win to help them stay atop the NFC South standings for another week.
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