The final week of the NFL regular season will pit two NFC West teams against one another. The Arizona Cardinals and San Francisco 49ers met in Mexico City in their first encounter of the season, and will face off in Santa Clara the second time around. In our NFL betting predictions for Week 18, we take a closer look at this Cardinals vs 49ers contest.
Cardinals vs 49ers Betting Pick
| ℹ️ The Pick: | Over 40 |
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This game will be played at Levi’s Stadium at 4:25 PM ET on Sunday, January 8, 2023.
Why Bet the Over:
✅ The offense of the 49ers has been playing at a high level since Brock Purdy took over as their quarterback. They have scored 30 or more points in four of the five games Purdy has appeared in, and will score in bunches again here.
✅ Arizona didn’t look completely lifeless in their last game against the Atlanta Falcons on the offensive end. David Blough led the Cardinals into scoring range multiple times, even though the Cardinals struggled to finish their possessions with touchdowns.
✅ The Niners will be going full tilt in this contest, as they are playing for playoff seeding. Bettors will not have to worry about the Niners resting players as a result.
NFL
Arizona Cardinals
San Francisco 49ers
Team Stats
Passing
Offense/Defense
| ARI | Passing | SF |
|---|---|---|
| 191 | CMP | 204 |
| 276 | ATT | 321 |
| 69.2 | CMP% | 63.6 |
| 197 | YDS/GM | 197.2 |
| 7.5 | Y/A | 6.5 |
| 6.8 | NY/A | 5.7 |
| 3 | INT | 11 |
| 15 | SK | 26 |
Defense/Offense
| ARI | Passing | SF |
|---|---|---|
| 221 | CMP | 202 |
| 323 | ATT | 306 |
| 68.4 | CMP% | 66.0 |
| 218.5 | YDS/GM | 251.1 |
| 7.2 | Y/A | 8.5 |
| 6.3 | NY/A | 7.7 |
| 5 | INT | 8 |
| 24 | SK | 21 |
Rushing
Offense/Defense
| ARI | Rushing | SF |
|---|---|---|
| 10 | G | 10 |
| 285 | ATT | 247 |
| 1494 | YDS | 1050 |
| 149.4 | Y/G | 105.0 |
| 5.2 | Y/A | 4.3 |
| 12 | TD | 13 |
| 1.2 | TD/G | 1.3 |
Defense/Offense
| ARI | Rushing | SF |
|---|---|---|
| 10 | G | 10 |
| 284 | ATT | 297 |
| 1275 | YDS | 1478 |
| 127.5 | Y/G | 147.8 |
| 4.5 | Y/A | 5.0 |
| 10 | TD | 10 |
| 1 | TD/G | 1 |
Special Teams
Offense/Defense
| ARI | Special Teams | SF |
|---|---|---|
| 9 | Punts/Ret | 9 |
| 106 | Punt/Yds | 160 |
| 11.8 | Punt/Y/R | 17.8 |
| 19 | Kick Off/Ret | 21 |
| 550 | Kick Off/Yds | 628 |
| 28.9 | Kick Off/Y/rt | 29.9 |
Defense/Offense
| ARI | Special Teams | SF |
|---|---|---|
| 14 | Punts/Ret | 16 |
| 160 | Punt/Yds | 132 |
| 11.4 | Punt/Y/R | 8.3 |
| 6 | Kick Off/Ret | 14 |
| 221 | Kick Off/Yds | 341 |
| 36.8 | Kick Off/Y/rt | 24.4 |
Scoring
Offense/Defense
| ARI | Scoring | SF |
|---|---|---|
| 10 | G | 10 |
| 12 | RshTD | 13 |
| 12 | RecTD | 11 |
| 17 | FGM | 16 |
| 18 | FGA | 17 |
| 23.8 | Pts/G | 22.2 |
Defense/Offense
| ARI | Scoring | SF |
|---|---|---|
| 10 | G | 10 |
| 10 | RshTD | 10 |
| 11 | RecTD | 13 |
| 22 | FGM | 26 |
| 23 | FGA | 30 |
| 22.0 | Pts/G | 25.0 |
Team Advanced Defense
| ARI | Defense | SF |
|---|---|---|
| 18.9% | Bltz% | 16.4% |
| 6.5% | Hrry% | 7.5% |
| 7.1% | QB Hit% | 9.3% |
| 19.1% | QB Prss% | 23.1% |
Injuries
| Name | Position | Injury | Status | Updated |
|---|---|---|---|---|
| Aaron Brewer | LS | Pectoral | Out | 01/08/23 |
| Antoine Wesley | WR | Hip | Out | 01/08/23 |
| Antonio Hamilton | CB | Hip | Out | 01/08/23 |
| Antwaun Woods | DT | Undisclosed | Out | 01/05/23 |
| Budda Baker | S | Shoulder | Out | 01/08/23 |
| Byron Murphy Jr. | CB | Back | Out | 01/08/23 |
| Chris Banjo | S | Concussion | Out | 01/08/23 |
| Colt McCoy | QB | Concussion | Out | 01/08/23 |
| Darrel Williams | RB | Hip | Out | 01/08/23 |
| DeAndre Hopkins | WR | Knee | Out | 01/08/23 |
| D.J. Humphries | OL | Back | Out | 01/08/23 |
| James Conner | RB | Shin | Out | 01/08/23 |
| Jonathan Ledbetter | DE | Knee | Out | 01/08/23 |
| Joshua Miles | OL | Undisclosed | Out | 01/08/23 |
| Justin Pugh | OL | Knee (acl) | Out | 01/08/23 |
| Kyler Murray | QB | Knee | Out | 01/08/23 |
| Lecitus Smith | OL | Gameday Inactive | Out | 01/08/23 |
| Marco Wilson | CB | Neck | Out | 01/08/23 |
| Marquis Hayes | OL | Knee | Out | 01/08/23 |
| Nate Hairston | CB | Undisclosed | Out | 01/08/23 |
| Nick Vigil | ILB | Hamstring | Out | 01/08/23 |
| Rashard Lawrence | DT | Shoulder | Out | 01/08/23 |
| Robbie Anderson | WR | Back | Out | 01/08/23 |
| Rodney Hudson | OL | Knee | Out | 01/08/23 |
| Rondale Moore | WR | Groin | Out | 01/08/23 |
| Trysten Hill | DT | Knee | Out | 01/08/23 |
| Zach Allen | DE | Hand | Out | 01/08/23 |
| Zach Ertz | TE | Leg | Out | 01/08/23 |
| Zaven Collins | ILB | Calf | Out | 01/08/23 |
| Billy Price | OL | Knee | Questionable | 01/06/23 |
| J.J. Watt | DE | Groin | Questionable | 01/06/23 |
| Kelvin Beachum | OL | Knee | Questionable | 01/06/23 |
| Lachavious Simmons | OL | Undisclosed | Questionable | 01/08/23 |
| Stephen Anderson | TE | Illness | Questionable | 01/04/23 |
| Isaiah Simmons | ILB | Ankle | Probable | 01/06/23 |
| Josh Jackson | CB | Hamstring | Probable | 01/08/23 |
| Leki Fotu | DT | Shoulder | Probable | 01/08/23 |
| Marquise Brown | WR | Wrist | Probable | 01/05/23 |
| Tanner Vallejo | ILB | Knee | Probable | 01/08/23 |
| Victor Dimukeje | OLB | Illness | Probable | 01/08/23 |
| Name | Position | Injury | Status | Updated |
|---|---|---|---|---|
| Aaron Banks | OL | Knee | Out | 01/08/23 |
| Ambry Thomas | CB | Ankle | Out | 01/08/23 |
| Dontae Johnson | CB | Knee | Out | 01/08/23 |
| Drake Jackson | DL | Gameday Inactive | Out | 01/08/23 |
| Dre Greenlaw | LB | Back | Out | 01/08/23 |
| Emmanuel Moseley | CB | Knee | Out | 01/08/23 |
| Hassan Ridgeway | DL | Pectoral | Out | 01/08/23 |
| Jason Verrett | CB | Knee | Out | 01/08/23 |
| Jimmy Garoppolo | QB | Foot | Out | 01/08/23 |
| Jordan Matthews | TE | Leg/knee | Out | 01/08/23 |
| Kevin Givens | DL | Knee | Out | 01/08/23 |
| Maurice Hurst | DL | Bicep | Out | 01/08/23 |
| Ross Dwelley | TE | Gameday Inactive | Out | 01/08/23 |
| Trey Lance | QB | Ankle | Out | 01/08/23 |
| Brock Purdy | QB | Oblique/rib | Questionable | 01/06/23 |
| Christian McCaffrey | RB | Ankle/knee | Questionable | 01/06/23 |
| Deebo Samuel | WR | Ankle/knee | Questionable | 01/06/23 |
| Elijah Mitchell | RB | Knee (mcl) | Questionable | 01/07/23 |
| Kalia Davis | DL | Undisclosed | Questionable | 01/08/23 |
| Arik Armstead | DL | Ankle/foot | Probable | 01/08/23 |
| Javon Kinlaw | DT | Back | Probable | 01/08/23 |
Betting Trends
| ARI | Betting Trends | SF |
|---|---|---|
| OVERALL | OVERALL | |
| 0-3-0 | Win/Loss/Tie | 3-0-0 |
| 2-1-0 | ATS W/L/P | 2-1-0 |
| 16.67 | Avg Score | 31.67 |
| 21 | Avg Opp Score | 22.33 |
| AWAY | HOME | |
| 1-2-0 | Win/Loss/Tie | 3-0-0 |
| 2-1-0 | ATS W/L/P | 3-0-0 |
| 20.33 | Avg Score | 35 |
| 20.33 | Avg Opp Score | 14.67 |
| ARI | Betting Trends | SF |
|---|---|---|
| OVERALL | OVERALL | |
| 0-5-0 | Win/Loss/Tie | 5-0-0 |
| 3-2-0 | ATS W/L/P | 4-1-0 |
| 17.4 | Avg Score | 32.6 |
| 23 | Avg Opp Score | 18.2 |
| AWAY | HOME | |
| 1-4-0 | Win/Loss/Tie | 5-0-0 |
| 2-3-0 | ATS W/L/P | 4-1-0 |
| 19.2 | Avg Score | 28 |
| 22.8 | Avg Opp Score | 12 |
| ARI | Betting Trends | SF |
|---|---|---|
| OVERALL | OVERALL | |
| 2-8-0 | Win/Loss/Tie | 9-1-0 |
| 5-5-0 | ATS W/L/P | 7-3-0 |
| 21.3 | Avg Score | 29 |
| 26.9 | Avg Opp Score | 17.5 |
| AWAY | HOME | |
| 4-6-0 | Win/Loss/Tie | 9-1-0 |
| 5-5-0 | ATS W/L/P | 8-2-0 |
| 19.9 | Avg Score | 26.8 |
| 23.9 | Avg Opp Score | 14 |
Head to Head
Teams Last 10
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Arizona Cardinals
The Arizona Cardinals come into the final week of the NFL regular season out of playoff contention. They are 4-12 and have lost six games in a row, leaving the tenure of Kliff Kingsbury in question heading into the offseason. It may be too late to relieve those concerns, but the Cardinals will look to close their regular season with a win this week.
If there is any reason to have confidence in the Cardinals this week, it is the fact that they are on the road. Arizona went 1-8 at home this season, and are 3-4 on the road coming into this matchup. While David Blough at quarterback is not the ideal scenario, Arizona’s track record on the road could be important here in Week 18.
San Francisco 49ers
The San Francisco 49ers enter Week 18 at 12-4 and as one of the favorites to win the Super Bowl. They also have a ton to play for this week, as they could finish anywhere between the first and third seed in the NFC playoffs depending on this week’s results. Here, the Niners will look to do their part to move up from second place to first to secure a first round bye.
While the Niners were expected to take a step backward after season-ending injuries to Jimmy Garoppolo and Trey Lance, that has not been the case. The Niners have been firing on all cylinders offensively with rookie Brock Purdy at the helm. The Niners will look to continue that trend to keep their momentum flowing prior to the postseason.
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