The Oklahoma Sooners will travel to Chicago to face the Marquette Golden Eagles in a neutral-site game on Friday afternoon. Both teams arrive off wins and are looking to build momentum by grabbing their most impressive win of the season in this game. Before tip-off from Chicago, you can continue reading to find my Oklahoma vs Marquette prediction in the betting markets.
Our Oklahoma vs Marquette Pick
Pick: Oklahoma -2.5
Confidence: ★★★★☆


Game Snapshot
- Matchup: Oklahoma Sooners vs Marquette Golden Eagles
- Date & Time: Friday, November 28, 2025, 2:00 PM ET
- Venue: Credit Union 1 Arena, Chicago, Illinois
- Broadcast: NBC
Key Storylines
- Neutral site situation: This game is set in Chicago, just a short drive from Milwaukee. That could give Marquette something close to a home‑game atmosphere. That could give the Golden Eagles a psychological edge in this game between opponents from the Big East and SEC.
- Recent form: Marquette snapped a two‑game skid with an 85–71 win over Central Michigan. Oklahoma earned a convincing 72–53 victory over Alcorn State in their last game. But both teams have yet to beat a power conference win going into this matchup.
- Styles may clash: Oklahoma’s offense is humming, averaging 88.5 points per game. Marquette gives up 74.5 points per game on average, which suggests the Sooners may have opportunities. But Marquette’s offense (83.4 PPG) is more than capable of testing the Alabama defense.
- Key contributors: Marquette guard Chase Ross is carrying much of the scoring burden (20.9 PPG). Oklahoma guard Nijel Pack is providing firepower and outside shooting. He leads the Sooners in scoring early in the year with 18.5 points per game.
Head‑to‑Head & Betting Trends
- This will be the first time the two programs meet, so there is no direct head‑to‑head history.
- The Sooners have failed to cover the spread in five of their first six games.
- Marquette isn’t much better against the spread with a 2-5 record against the number.
- The Sooners are 3-3 in the over/under market this year.
- Marquette has gone over the total four times in seven games.
Oklahoma vs Marquette Model Projection
Pick: Oklahoma 85 – Marquette 82
Win Probability: OU 57%, Marquette 43%
Final Thoughts
Oklahoma will try to play more possessions than Marquette in this game. And with Oklahoma having a superior offense, we should see the Sooners get the win and cover the spread in this matchup. I’ll take Washington to get the job done against a Marquette team that is playing close to its own backyard in Chicago.

