The LA Clippers and Los Angeles Lakers will meet in a crosstown rivalry game on Tuesday night in the NBA. These teams no longer share an arena, which means the Lakers are actually the home team at Crypto.com Arena. The Lakers are favored on their home floor as they look for their fifth win in a row. Before tip from LA, continue reading to get my breakdown of this game, including my Clippers vs Lakers prediction.
Our Clippers vs Lakers Pick
- Pick: Lakers -6.5
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: LA Clippers @ Los Angeles Lakers
- Date & Time: Tuesday, November 25, 2025, 11:00 PM ET
- Venue: Crypto.com Arena, Los Angeles, California
- Broadcast: NBC
Key Storylines
- The Clippers’ injury crisis continues to be a factor for them this season. Bradley Beal is out for the season with a hip fracture, Derrick Jones Jr. remains sidelined with a knee issue, and Bogdan Bogdanović is questionable.
- Kawhi Leonard returned to the floor for the Clippers on Sunday. He scored 20 points in 26 minutes and he will be a very important figure for the Clippers for as long as he’s on the floor without Beal to help them offensively.
- On the Lakers’ side, Deandre Ayton will miss the game due to a right knee contusion suffered in their last outing. That could be impactful against a Clippers team that has one of the better traditional big men in the league in Ivica Zubac.
- This game is part of the NBA Cup group stage, giving both teams extra motivation to perform. Both of these teams are tied atop their group in the Western Conference with 2-0 records in group play thus far. The winner of this contest will likely advance to the next round, while the loser has some catching up to do.
- The Lakers have won four games in a row coming into this matchup, while the Clippers have dropped four of their last five games. To be fair, the Clippers have played much tougher competition of late, but the Lakers do have momentum on their side entering this rivalry game.
Head-to-Head & Betting Trends
- This is the first game between the Lakers and Clippers so far this season.
- The Lakers are 11-5 against the spread this season. That is the second-best record in the league against the spread.
- The Clippers have the second-worst record in the NBA against the spread at 5-12.
- The over is 10-6 in games involving the Lakers so far this year.
- The over is 10-7 in the Clippers’ games thus far.
Clippers vs Lakers Model Projection
Score Projection: Clippers 110 – Lakers 121
Win Probability: Lakers 68%, Clippers 32%
Final Thoughts
It is going to be exciting to see the duo of James Harden and Kawhi Leonard take on the duo of Luka Doncic and LeBron James in this game. But I think that the Lakers have the upper hand when it comes to the rest of these rosters. As long as Zubac doesn’t have a monster game for the Clippers, I expect the Lakers to win and cover the number in this matchup from LA.
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