The 2025 college football season continues with Week 6 action set for this Saturday. We have broken down the board and made our college football best bets for this week. Continue reading to find out what our experts like in the betting markets in Week 6 and every week of the college football season.
College Football Week 6 Best Bets & Predictions
CFB Best Bet #1: Louisville -7 (-110) over Virginia
Our top pick for Week 6 of the college football season is for Louisville to cover the spread at home against Virginia. The Cavaliers are coming off an impressive home upset win over the Florida State Seminoles in their last outing. But we expect a letdown from Virginia here and for Louisville to continue their winning ways following an impressive comeback win on the road against Pitt.
2025 College Football Best Bets Record: 3-3 (-0.3 units)
2024 College Football Best Bets Record: 19-16 (+1.93 units)
2023 College Football Best Bets Record: 18-15-1 (+1.70 units)
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With years of hands-on experience in sports betting, our team of analysts is your trusted source for college football best bets throughout the 2025 season. From the opening kick-off of the season to the National Championship, we bring you carefully researched picks designed to maximize your betting potential. Leveraging deep knowledge of NCAA football, advanced data analytics, and betting strategies we use in our own bets, we offer insights that go beyond the basics.
Whether you’re looking for picks against the spread, moneyline predictions, or over/under picks, our team delivers consistent, data-backed advice you can count on. As passionate bettors ourselves, we understand what it takes to uncover value and stay ahead of the game. Trust our proven track record and commitment to providing reliable, actionable recommendations for key college football matchups this season.
The Best College Football Bets This Week
Those looking for college football betting picks should look no further than this page. Our college football experts use their betting strategies to provide CFB picks on a regular basis. College football bettors who want to turn a profit wagering on the sport should be sure to bookmark this page and come back to it each week. This is where our weekly college football predictions will be, and you will not want to miss them.
How We Make Our College Football Picks
Each week throughout the college football season, our expert college football handicappers go through the schedule of games across the sport. They do their own analysis and data modeling to make their own game projections and set their own lines for each contest. Those projections are then compared to the actual lines for each game to determine where the most value lies throughout the entire college football slate.
Types Of College Football Bets
We offer college football picks on a weekly basis here, covering all of the major betting markets that come with wagering on this sport. Below is a quick breakdown of the different betting markets that bettors can find on this page from Week 0 all the way through to the College Football Playoff championship game at the end of the year.
Spread Bets
Point spread bets ask bettors to pick which team will win a game, after the point spread amount is added to or subtracted from one team’s score. Betting on point spread favorites means points are subtracted from that team’s score, while underdogs have points added to their total. Either way, the team with the higher score after that point spread is applied will be the winner for the purposes of this market.
Over/Under Bets
With over/under betting, the team that wins a game is not important. Instead, it is up to bettors to predict how much scoring will take place in a college football game. Sportsbooks set a total for each matchup, and bettors are then asked to pick whether the game will go over or under that total. In college football, there can be huge differences in the quality of offenses and defenses across the country, and bettors have to be aware of those differences.
Moneyline Bets
Moneyline betting asks bettors to simply predict which team will win each game during the college football season. This is not always easy to do, as upsets can happen to even the best programs in the country. But with this betting market, there are no spreads or point totals that need to be taken into consideration, as bettors simply need to pick who the winner of each game will be.
Can You Bet On College Football Props?
Whether or not there are college football prop bets to wager on varies by sportsbook and by state. Many states do not allow for prop betting on college football games, while some states do. Bettors should check for the legal status of college football player props where they are to make sure that they are betting on these markets legally.
College Football Betting Strategies
When betting on college football, having a strategy is so important to having success while placing wagers. Fortunately, our experts have plenty of strategies that they use to place the best bets possible on a weekly basis. Below are some of those strategies, which bettors can integrate into their own college football handicapping.
Don’t Be Afraid to Dig Deep
The college football media will often focus on teams like Ohio State and Alabama with their coverage, along with the other top College Football Playoff contenders. But much of the value when betting on college football games can be found by looking at smaller games in smaller conferences. If nothing else, bettors should be sure to take a look at some of the less mainstream offerings, as there could be some hidden gems out there.
Stay Within Yourself
While bettors should not be afraid to look at smaller games and conferences in college football, bettors should also manage their money intelligently throughout the season. It is smart to set a budget and stick to that budget on a weekly and yearly basis. Bettors should also avoid chasing losses to avoid unnecessary drain on their bankroll.
Remember These Are Just Kids
Along with the advice listed above, bettors should also remember that college football players are just college kids. This means that mistakes could happen that would not normally happen in the pros, or that players may struggle adapting to pressure because they have not experienced much of it in their young careers. Because of that, bettors should not wager more than they are absolutely comfortable with on any college game.
More Expert Football Picks
Along with our CFB picks for this week, bettors can also click the link in this paragraph to get our best college football parlays this week. These parlay bets scour the college football schedule each week to attempt to turn small wagers into larger payouts.
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