Detroit Lions vs Baltimore Ravens Prediction – 9/22/2025
The Detroit Lions will head to Baltimore to close out Week 3 on Monday Night Football against the Baltimore Ravens. Both teams bounced back from Week 1 wins with victories in the second week of the season. They will try to get above the .500 mark for the first time this season with a victory in this primetime matchup. Continue reading to get my thoughts on this huge regular-season game and to get my Lions vs Ravens prediction.
Our Lions vs Ravens Pick
- Pick: Over 51.5
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Detroit Lions vs Baltimore Ravens
- Date & Time: Monday, September 22, 2025, 8:15 p.m. ET
- Venue: M&T Bank Stadium, Baltimore, MD
- Broadcast: ESPN/ABC
Key Storylines
- Baltimore has scored 81 points across two games, while Detroit has scored 65, including 52 last week against the Chicago Bears. Both offenses are operating at a very high level.
- Both teams are 1-1 on the season, losing to a playoff-caliber team in Week 1 before beating softer competition in Week 2. One team will pass its biggest test of the season this week, barring a tie.
- The Packers are playing well in the NFC North and there are multiple teams who can challenge the Ravens in the AFC North. Both teams are looking to avoid a loss that could put them behind the eight-ball in their division.
- The Lions were 8-0 on the road in the 2024 regular season, while the Ravens went 6-2 at home. Something has to give here.
Quarterback Play
Jared Goff, DET: Goff is 54-for-67 with 559 yards, six touchdowns, and one interception. He put on a show at home in Week 2 against an overmatched Bears team. Goff will look to continue to find throws to Amon-Ra St. Brown and Jameson Williams to take down the Ravens on the road.
Lamar Jackson, BAL: Jackson enters Week 3 at 33-for-48 passing with 434 yards, six touchdowns, and no interceptions. Jackson is also incredibly dangerous with his legs and the Lions will have to be incredibly disciplined to avoid giving Jackson running lanes when he drops back to throw.
Betting Trends & H2H
- Both teams are 1-1 against the spread going into Week 3.
- Ravens games have gone 2-0 to the over heading into this contest.
- The Lions have gone over the total in one game and under the total in one game.
Lions vs Ravens Model Projection
Score Projection: Lions 27 – Ravens 31
Win Probability: Lions 42%, Ravens 58%
Final Thoughts
I think that the Ravens end up winning an exciting game in Baltimore on Monday night. But my top pick for this contest comes in the over/under market. There, I think that we will see the over cash in what should be a really fun matchup between these two teams. These teams both scored over 40 points last week. While I don’t think either team gets there in this contest, they will combine to go over 51.5 points.
