NFC West rivals will meet on Sunday when the Arizona Cardinals face the Seattle Seahawks in Week 10 of the NFL season. Seattle enters this week at the top of a highly competitive division, while the Cardinals come into this week in last place and with their backup quarterback set to start under center. Here, I break down this division matchup and give you my Cardinals vs Seahawks prediction before kickoff.
Our Cardinals vs Seahawks Pick
- Pick: Cardinals +6.5
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Arizona Cardinals @ Seattle Seahawks
- Date & Time: Sunday, November 9, 2025, 4:05 p.m. ET
- Venue: Lumen Field, Seattle, WA
- Broadcast: CBS
Key Storylines
Kyler Murray has been placed on injured reserve with a foot injury and Jacoby Brissett is officially taking over as the starter at quarterback for the Cardinals. Murray has thrown for 962 yards, six touchdowns, and three interceptions in five starts. He also leads the team in rushing with 173 yards. Brissett has stepped in and thrown for 860 yards, six touchdowns, and one pick in three starts. Arizona’s scoring has jumped from 20.6 points per game under Murray to 25.7 points per game under Brissett.
The Seahawks arrive into this game with plenty of momentum. They are 6‑2 overall and coming off a dominant 38‑14 win in Washington on Monday night. Seattle has won three games in a row coming into this week and they need to keep winning to stay on top of the NFC West. Both the Rams and 49ers have six wins this season and they play each other this week. A Seattle loss would likely put them behind someone else in the NFC West standings.
Quarterback Play
Brissett has performed well in his opportunities to start for the Cardinals. Arizona’s offensive line has allowed pressure on 35 % of dropbacks. But Brissett has had success in spite of the issues on the offensive line. Against a Seahawks defense trained to rush the passer, Brissett’s durability and poise will be tested.
Sam Darnold is the starting quarterback for Seattle. He is coming off a 330‑yard, four‑touchdown performance against Washington. Their pass protection has held up and their rushing attack has helped keep defenses honest to give Darnold the best chance to have success.
Betting Trends & H2H
- Seattle defeated Arizona 23-20 in Glendale earlier this season.
- Seattle is 6-2 against the spread this season.
- Arizona is 5-3 against the spread for the year.
- Arizona is 4‑0 against the spread on the road this season.
- Seattle is 2‑2 against the spread at home.
- The over is 4‑4 in Cardinals games this year and 5‑3 in Seahawks games.
Cardinals vs Seahawks Model Projection
Score Projection: Seahawks 28 – Cardinals 24
Win Probability: Cardinals 30%, Seahawks 70%
Final Thoughts
The Seahawks should get the win in this matchup from the Pacific Northwest. But I am going to take the points with the Cardinals in this contest. I would argue that the Cardinals are better offensively with Brissett right now than they are with Murray. Look for Arizona to do enough to keep this game within one possession even if the Seahawks get a big win for their NFC West title hopes.
