The upcoming clash between the Philadelphia 76ers and the Detroit Pistons on Friday should be an interesting one. Detroit comes in at 10‑2 and is the hottest team in the NBA. Philadelphia is 7‑4 and is facing several key injury questions. Before tip-off from Detroit continue reading to get my 76ers vs Pistons prediction for this matchup.
Our 76ers vs Pistons Pick
- Pick: Pistons -5.5
- Confidence: ★★★☆☆
Game Snapshot
- Matchup: Philadelphia 76ers @ Detroit Pistons
- Date & Time: Friday, November 14, 2025, 7:30 p.m. ET
- Venue: Little Caesars Arena, Detroit, Michigan
- Broadcast: NBA League Pass
Key Storylines
Detroit enters this game after a strong start (10‑2) and home‑court advantage working in their favor. Their young core is led by Cade Cunningham (27.5 PPG, 9.9 AST) and Jalen Duren (19.4 PPG, 12.0 REB) and it has gelled quickly. The Pistons have won eight games in a row coming into this contest and will try to get another important win here.
Detroit faces a daunting injury list. Key contributors such as Jaden Ivey, Tobias Harris, and Ausar Thompson are unavailable. Cunningham is questionable with a hip contusion and Duren is listed as questionable with an ankle sprain.
Philadelphia has had to manage without Joel Embiid, who is officially out with right knee soreness. Also missing is Paul George (left knee recovery). The loss of Embiid is huge as his interior dominance and rim protection are elite. The 76ers will lean heavily on Tyrese Maxey (32.1 PPG, 8.3 AST) to carry the offensive load with their other stars injured.
Head‑to‑Head & Betting Trends
- Detroit has gone 8‑4 against the spread this season.
- The 76ers are 9-2 against the spread this year.
- Philadelphia is 7-4 to the over going into this matchup.
- Detroit is 6-5-1 in the over/under market heading into Friday night.
- Detroit won the first meeting between these teams in Philadelphia this year.
Best Player Props to Watch
| Player | Prop |
|---|---|
| Tyrese Maxey | Over 30.5 points |
| Cade Cunningham | Under 28.5 points (if healthy) |
76ers vs Pistons Model Projection
Score Projection: Pistons 117 – 76ers 109
Win Probability: Pistons 58%, 76ers 42%
Final Thoughts
I will take the Detroit Pistons to get a win and cover the spread at home over the 76ers on Friday night. The Pistons are on fire of late and they should continue their winning ways here against a Sixers team that is ravaged by injuries once again. Embiid’s absence will be a huge problem for Philadelphia and we should see Duren and Detroit take advantage of that. As long as Cunningham and Duren can play, the Pistons should cover the number on Friday night.
