The Detroit Pistons and Indiana Pacers will face off on Monday in a contest that pits one of the league’s hottest teams against a struggling opponent reeling from injuries. The Pistons have been rolling, while the Pacers are desperate to steady the ship. Before these Central Division rivals do battle on the court, continue reading for my Pistons vs Pacers prediction.
Our Pistons vs Pacers Pick
Pick: Detroit Pistons −10.5
Confidence: ★★★★☆
Get all of our NBA best bets before tip-off!
Game Snapshot
- Matchup: Detroit Pistons @ Indiana Pacers
- Date & Time: Monday, November 24, 2025, 7:00 PM ET
- Venue: Gainbridge Fieldhouse, Indianapolis, Indiana
- Broadcast: NBA League Pass
Key Storylines
The Pistons are surging, riding 12-game winning streak into this matchup. They recently posted their 12th straight win with a dominant performance over Milwaukee, thanks to Cade Cunningham’s near triple-double and Jalen Duren’s strong inside presence. Detroit’s offense has been highly efficient, averaging nearly 119.5 points per game, while their defense remains stingy with 112.4 points per game allowed. Their balance and depth have made them one of the most well-rounded teams in the league.
On the other side, the Pacers are mired in a brutal injury crisis. Key rotation pieces are unavailable all over the place for Indiana. Tyrese Haliburton is out for the season and others like Obi Toppin, Aaron Nesmith, and Quenton Jackson are hurt. Indiana is averaging just 110.1 points per game while giving up 122.9, putting them near the bottom of the league in both offense and defense. Their lack of firepower and defensive rebounding issues have exposed serious vulnerabilities.
If Indiana is going to have a chance in any game this season, it’s going to be because Pascal Siakam has a huge game. Siakam is being asked to do way too much this year given all of Indiana’s injuries and the fact that Myles Turner went to Milwaukee. Siakam is averaging just under 25 points per game and even that hasn’t been enough to help the Pacers win consistently.
Head-to-Head & Betting Trends
- The Pistons defeated the Pacers 127–112 in their first meeting this season.
- Detroit is an NBA-best 12-4 against the spread this year.
- Indiana is 7-9 against the spread going into Monday night.
- The Pacers have stayed under the total in 10 of their first 16 games.
- Detroit is 9-6-1 to the over going into this matchup.
Best Player Props to Watch
| Player | Prop to Watch |
|---|---|
| Cade Cunningham | Over 27.5 Points |
| Jalen Duren | Over 12.5 Rebounds |
| Pascal Siakam | Over 23.5 Points |
| Andrew Nembhard | Under 6.5 Assists |
Pistons vs Pacers Model Projection
Score Projection: Pistons 124 – Pacers 108
Win Probability: Pistons 75%, Pacers 25%
Final Thoughts
All signs point to a convincing Pistons win in this game. With Detroit in full stride and Indiana shorthanded, this feels like a spot where the Pistons can impose their will over 48 minutes. I will lay the points with the Pistons, who should win their 13th straight game while dropping the rival Pacers to 2-15 on the season.
Affiliate Disclosure
ATS.io features affiliate links to licensed online casinos, sportsbooks, and gambling platforms. That means if you click on them and end up signing up or making a deposit, we might earn a commission at no extra cost to you. We only work with licensed and reputable online casinos, social casinos and sportsbooks. Our content whether it’s reviews, guides, or betting tips is written with the goal of being honest, helpful, and based on real experience. While we do earn through affiliate partnerships, it doesn’t affect our recommendations. If a site isn’t safe or doesn’t meet our standards, we won’t promote it. Simple as that. We also take responsible gambling seriously. We encourage all our readers to gamble safely, set limits, and know when to take a break. Have questions? Feel free to reach out. We’re always happy to chat.
