The St. Louis Blues will face the Buffalo Sabres on Thursday night KeyBank Center in Buffalo. Both of these teams have struggled early in the year and will try to get a win to bring them out of their recent funks here. Before the puck drops in Buffalo, continue reading to get my Blues vs Sabres prediction for Thursday night.
Our Blues vs Sabres Pick
- Pick: Buffalo Sabres Moneyline
- Confidence: ★★★☆☆
Game Snapshot
- Matchup: St. Louis Blues vs Buffalo Sabres
- Date & Time: Thursday, November 6, 2025, 7:00 PM ET
- Venue: KeyBank Center, Buffalo, New York
- Broadcast: ESPN+
Key Storylines
Recent form
Buffalo sits at 5-4-4 entering this game. They have lost four of their last five games, but all five of those games have yielded at least a point for Buffalo. They need to be better at closing games, especially in overtime, but things aren’t as bad as the win/loss record would indicate for the Sabres of late.
St. Louis arrives at 4-8-2 after a 6-1 loss to the Washington Capitals in their last game. They’re averaging only 2.71 goals per game and allowing 4.14 goals per game, which ranks them near the bottom of the league defensively. St. Louis has lost four of its last five games as well and will try to end that run with a strong performance in this game.
Goaltending
Alex Lyon is likely to start this game in net for the Sabres. He enters this game at 3-4-3 with a 2.81 GAA and .915 save percentage. St. Louis’ Jordan Binnington is 3-5-2 with a 3.34 GAA and .859 save percentage. But we could see Binnington replaced here as the Blues are on the second game of a back-to-back as they travel in from Washington overnight.
Key skaters
St. Louis:
- Pius Suter leads with 9 points (5 goals, 4 assists).
- Jordan Kyrou and Robert Thomas each have 8 points
- Kyrou: 4 goals, 4 assists
- Thomas: 2 goals, 6 assists
- Jake Neighbours has 7 points with a team-high 6 goals. But he is on IR, which has been devastating for the Blues of late.
Buffalo:
- Alex Tuch leads the Sabres with 12 points (5 goals, 7 assists).
- Tage Thompson is up to 10 points (5 goals, 5 assists).
- Rasmus Dahlin has 9 points and leads the team with 8 assists.
Best Player Props
| Player | Stat | Prop |
|---|---|---|
| Alex Tuch (Sabres) | Points | Over 0.5 |
| Tage Thompson (Sabres) | Goals | Over 0.5 |
| Jordan Kyrou (Blues) | Goals | Over 0.5 |
Betting Trends & H2H
- This is the first of two times these teams will play each other in the regular season.
- Buffalo is 6-7 on the puckline this year.
- St. Louis is 5-9 on the puckline for the season.
- Buffalo is 6-5-2 favoring the over in their games this year.
- St. Louis is 9-5 favoring the over for the season.
Blues vs Sabres Model Projection
Score Projection: Buffalo 4 – St. Louis 2
Win Probability: Buffalo 65%, St. Louis 35%
Final Thoughts
The Sabres should have the upper hand against the Blues in this contest. St. Louis is at an extreme rest disadvantage and had to travel to Buffalo overnight for this game. I’ll take the Sabres to win on the moneyline at home as they should take advantage of the fatigue surrounding this St. Louis team.
