The Cleveland Cavaliers host the Memphis Grizzlies on Saturday in a game that is expected to be one-sided. Cleveland enters with a winning record and is looking to shake off their recent struggles against a Grizzlies team that is in the midst of a losing streak. Not sure what to bet in this matchup in the NBA? Find out who I like below as I make my Grizzlies vs Cavaliers prediction.
Our Grizzlies vs Cavaliers Pick
Pick: Cavaliers -10.5
Confidence: ★★★★☆
Game Snapshot
- Matchup: Memphis Grizzlies @ Cleveland Cavaliers
- Date & Time: Saturday, November 15, 2025, 5:00 PM ET
- Venue: Rocket Arena, Cleveland, Ohio
- Broadcast: NBA TV
Key Storylines
- Injury concerns: Cleveland is playing without Darius Garland, Max Strus, and Jaylon Tyson. Meanwhile, Memphis is also dealing with injuries. Brandon Clarke, Ty Jerome, and Scotty Pippen Jr. are all out. Zach Edey is also questionable.
- Recent form: The Grizzlies have lost three in a row heading into this game. All three of those losses came by double-digits against the Thunder, Knicks, and Celtics. Cleveland has dropped two of its last three games and they will try to get back on track here.
- Three-point battle: Cleveland is averaging 16.2 makes per game from deep, while Memphis gives up around 14.5 per contest. The Cavs could have a potential edge in long-range scoring, especially with Donovan Mitchell expected to play.
- Offensive mismatch: According to efficiency metrics, Memphis is among the bottom-tier offenses this season. Cleveland ranks stronger in most key offensive metrics. But the NBA isn’t played on paper and the Cavs need to be solid offensively to win this game.
Head-to-Head & Betting Trends
- The Grizzlies are 3-10 against the spread so far this season.
- Cleveland isn’t much better than Memphis against the spread at 4-10.
- Cleveland’s games have gone over the total 8 times and under the total 5 times.
- The under has cashed in 8 of Memphis’ 13 games.
Best Player Props to Watch
| Player | Prop |
|---|---|
| Donovan Mitchell | Over 28.5 Points |
| Jaren Jackson Jr. | Under 5.5 Rebounds |
Grizzlies vs Cavaliers Model Projection
Score Projection: Cavaliers 122 – Grizzlies 110
Win Probability: Cavaliers 65%, Grizzlies 35%
Final Thoughts
The Grizzlies have made a habit of losing games by double-digits lately. I expect that trend to continue in this game on the road against a very good Cavaliers team. Look for Cleveland to improve to 5-2 on their home floor for the season with a win that would drop Memphis to 1-5 on the road. I’ll lay the points with Cleveland in this one.
