Milwaukee Brewers vs San Francisco Giants Pick – 4/21/2025

Milwaukee Brewers vs San Francisco Giants Betting Preview

As the San Francisco Giants prepare to host the Milwaukee Brewers on April 21, 2025, both teams find themselves in contrasting positions in the standings. The Giants boast a solid 14-8 record, while the Brewers sit a game under .500 at 12-10.

In this matchup, the Giants are expected to start Robbie Ray, who holds a 3-0 record with an ERA of 4.19. While Ray is not ranked highly at 152nd among starting pitchers, he has shown a knack for getting results. However, his projected stats indicate he may struggle, allowing an average of 2.6 earned runs and 4.9 hits per game. The Giants' offense, ranked 18th overall, will need to leverage Ray's ability to limit damage against a Brewers lineup that has been inconsistent.

On the other side, Quinn Priester will take the mound for Milwaukee. Although he holds an impressive 0.90 ERA, projections suggest he may also be due for some regression, given his higher xFIP of 4.09. With the Giants' offense being among the most strikeout-prone in the league, Priester's low strikeout rate could play to his advantage, especially if he can keep the ball in the park.

Given the overall performance of the Giants' bullpen, which ranks 2nd in MLB, they have the upper hand in this matchup. San Francisco is favored with a moneyline of -145, implying a solid chance for a victory. Fans can expect an intriguing game as both teams look to establish momentum in this first of a series.

Quick Takes Milwaukee Brewers:

Among all the teams in action today, the strongest infield defense belongs to the Milwaukee Brewers.

• Defense is an integral part of preventing hits and runs.

The San Francisco Giants have just 1 same-handed RP in their bullpen, so Christian Yelich stands a good chance of never losing the platoon advantage against the 'pen all game.

• Hitters perform worse against pitchers of the same handedness (i.e. righty-vs-righty), and being able to avoid those matchups against the bullpen boosts performance and creates hidden edge.

William Contreras has an 89th percentile opposite-field rate on his flyballs (36.1%) and has the good fortune of hitting them in the direction of the game's 2nd-shallowest RF fences in today's matchup.

• This player's skill set matches up particularly well with the park he's in today, which may lead to better-than-usual performance.

Quick Takes San Francisco Giants:

Robbie Ray is an extreme flyball pitcher (41.3% FB% via the leading projection system, THE BAT) and has the benefit of pitching in the #28 HR venue in the league in this matchup.

• This pitcher's skill set matches up particularly well with the park he's in today, which may lead to better-than-usual performance.

Mike Yastrzemski is an extreme flyball batter and squares off against the strong outfield defense of Milwaukee (#1-best of the day).

• This player's skill set matches up poorly with the opposing team's defensive strength, which may lead to worse-than-usual performance.

Patrick Bailey, the Giants's expected catcher in today's game, profiles as an elite pitch framer according to the leading projection system (THE BAT).

• Pitch framing is a catcher's ability to make a ball look like a strike to the umpire, "stealing" strikes for his pitcher. This leads to more positive outcomes (like strikeouts) and fewer negative ones (like walks or earned runs).

Game Trends

• Brice Turang has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+8.65 Units / 28% ROI)

Milwaukee Brewers vs San Francisco Giants Prediction

Predicted Final Score: Milwaukee Brewers 4.44, San Francisco Giants 4.52

• Date: April 21, 2025
• Venue: Oracle Park
• Starting Pitchers:
  • Quinn Priester - Brewers
  • Robbie Ray - Giants

For more on today's game check out the comprehensive statistics, betting odds, and trends below. Be sure to check out all our free MLB picks here.