Boston Red Sox vs Philadelphia Phillies Pick – 7/22/2025

Tuesday night at Citizens Bank Park brings an interleague showdown between the Boston Red Sox and Philadelphia Phillies. These teams played a thrilling extra-inning game on Monday night. Philadelphia won that game and will look for a second straight win over the Sox tonight. Continue reading to get my analysis for this game, which includes my Red Sox vs Phillies prediction.

Our Red Sox vs Phillies Pick

  • Pick: Phillies -1.5
  • Confidence: ★★★★☆
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Game Snapshot

  • Matchup: Boston Red Sox @ Philadelphia Phillies
  • Date & Time: Tuesday, July 22, 2025, 6:45 PM ET
  • Starting Pitchers: Richard Fitts (BOS) vs. Cristopher Sánchez (PHI)
  • Stadium: Citizens Bank Park, Philadelphia, PA
  • Broadcast: TBS

Key Storylines

Pitching Matchup

Boston’s rotation has taken hits this season. Injuries to Kutter Crawford and Tanner Houck have forced them to rely on less reliable arms. Richard Fitts is 1–3 with a 4.28 ERA in eight appearances this season. He has shown flashes of competence but remains unproven against elite offenses like the one he is going to face tonight.

The Phillies will counter with Cristopher Sanchez. Sanchez is 8–2 and has a 2.50 ERA. He will be expected to outperform Fitts on the mound in this game and have the Phillies in a position to win this contest when he exits.

Bullpen Usage

I think that the bullpen situation going into this game is especially interesting. Both teams had to pitch into a 10th inning last night. But neither bullpen struggled too much at limiting damage either. I’m inclined to think that the combination of those two factors is a wash and that we should see both pens close to full strength here.

Recent Team Streaks

  • Red Sox: Boston has lost three of its first four games coming out of the All-Star break. They have played a brutal schedule since the break ended, facing the Cubs and Phillies.
  • Phillies: Philadelphia has won three of its last five games. They have alternated between wins and losses during that span.

Best Player Props

PlayerPropPick
Kyle SchwarberHome RunsOver 0.5
Cristopher SánchezStrikeoutsOver 6.5
Trea TurnerTotal BasesOver 1.5
  • The Phillies have won the only game of the season series between these teams so far this year.
  • With Monday’s win, the Phillies improved to 32-18 at home for the season.
  • Boston is now 5-10 in extra-inning games this year. The Phillies are 6-4 in such situations.

Red Sox vs Phillies Model Projection

Score Projection: Phillies 4 – Red Sox 2

Win Probability: Phillies 62%, Red Sox 38%

Final Thoughts

I like the Phillies to get a second straight win in this series over the Boston Red Sox. Sanchez gives the Phillies a massive advantage in the starting pitching department for the second straight night. And with the Red Sox struggling coming out of the break against elite National League competition, I don’t see them doing enough to keep this game within a run. Take the Phillies to cover the runline tonight.


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Home MLB Picks Boston Red Sox vs Philadelphia Phillies Pick – 7/22/2025