The UConn Huskies will face the Syracuse Orange in a non-conference matchup on Saturday in Syracuse. UConn got a win over an FCS opponent last week while Syracuse took a loss to an opponent from the SEC. Syracuse is favored to move both of these teams to 1-1 on the season by the end of the week. Before kickoff from Central New York, continue reading to get my UConn vs Syracuse prediction for Saturday’s matchup.
Our UConn vs Syracuse Pick
- Pick: Syracuse -6.5
- Confidence: 3/5
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Game Snapshot
- Matchup: UConn Huskies vs Syracuse Orange
- Date & Time: Saturday, September 6, 2025, 12:00 PM ET
- Venue: JMA Wireless Dome, Syracuse, NY
- Broadcast: ESPN+
UConn vs Syracuse Odds
| Spread | Moneyline | Total | |
|---|---|---|---|
| Syracuse | -6.5 | -240 | 57.5 |
| UConn | +6.5 | +200 | 57.5 |
Key Storylines
- Syracuse’s Home Advantage: The Orange have a strong home record with wins in seven of their last eight games at the Dome.
- Syracuse Looks to Bounce Back: Syracuse lost 45-26 against Tennessee in their season opener last week. There isn’t a ton of shame in losing on the road to an elite SEC opponent. The real test will be how Syracuse responds to that setback this week.
- UConn’s Momentum: The Huskies got a dominant 59-13 victory over Central Connecticut State in their season opener. That was the third straight win for UConn dating back to last season. But their last loss came against this same Syracuse team that they are facing this weekend.
Quarterback Play
Syracuse quarterback Steve Angeli threw for 274 yards and a touchdown their season-opening loss to Tennessee. The problem for Syracuse last week was not their quarterback. It was the Orange defense that let them down and Angeli should lead his team to a win if he performs similarly to how he did last week.
UConn quarterback Joe Fagnano had an impressive performance in the season opener for the Huskies. He completed 18 of 25 passes for 260 yards and three touchdowns. But that was against an FCS team and not against a power conference team like Syracuse.
Betting Trends & H2H
- UConn covered the spread in their 46-point win over Central Connecticut State.
- Syracuse failed to cover the spread in their season opener against Tennessee.
- Both teams went over the totals in their first games of the season last week.
- These teams are 6-6 against each other all-time. Syracuse has won five games in a row over UConn dating back to 2012.
UConn vs Syracuse Model Projection
Score Projection: Syracuse 34 – UConn 25
Win Probability: Syracuse 70%, UConn 30%
Final Thoughts
Syracuse should look a lot better this week than they did against a very good Tennessee team last week. Angeli will have another solid game for the Orange and the UConn offense will look like a completely different team now that they are not facing a low-level FCS opponent. I’ll lay the points with Syracuse in this contest between former Big East rivals.
