The San Francisco 49ers and Seattle Seahawks will play in an NFC West rivalry game in Week 1 of the NFL season on Sunday. San Francisco had a disappointing 2024 season and will look to get back into the NFC title picture. Seattle has a new starting quarterback leading them and will face a big test right out of the gate. Before kickoff from the Pacific Northwest, continue reading to get my 49ers vs Seahawks prediction.
Our 49ers vs Seahawks Pick
- Pick: Seattle Seahawks +2.5
- Confidence: 3/5
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Game Snapshot
- Matchup: San Francisco 49ers vs Seattle Seahawks
- Date & Time: Sunday, September 7, 2025, 4:05 p.m. ET
- Venue: Lumen Field, Seattle, WA
- Broadcast: FOX
49ers vs Seahawks Odds
| Spread | Moneyline | Total |
|---|---|---|
| 49ers -2.5 | 49ers -135 / Seahawks +114 | 43.5 |
Key Storylines
- The 49ers offense is set to look different this year than it did a season ago. Deebo Samuel is a Washington Commander now and the Niners won’t have his versatility to keep opponents off-balance. Brandon Aiyuk is also injured and that could hurt the Niners on offense.
- The Seahawks have also made some huge changes to their offense. Sam Darnold will be their new starting quarterback and they got rid of DK Metcalf to replace him with Cooper Kupp on the outside. Those changes will be tested right away against a good 49ers defense.
- This is a division matchup and that means some huge importance for both teams to get a win in Week 1. A loss would put the team that takes it a game behind the winner in the NFC West standings and will also have tiebreaker implications later in the season.
Quarterback Play
- Brock Purdy brings stability and experience to the 49ers offense. He is aiming to exploit weaknesses in Seattle’s secondary. But Purdy has to prove himself as more than a game manager this year if the Niners are going to make another deep playoff run.
- Sam Darnold will rely on his offensive line and receiving corps to keep Seattle competitive in their home opener. Darnold had a big year for the Minnesota Vikings last year but fell apart in the playoffs. He will try to shake off his late-season struggles at the start of this year.
Best Player Props
| Player | Prop |
|---|---|
| Christian McCaffrey | Under 75.5 Rushing Yards |
| Brock Purdy | Under 1.5 Passing Touchdowns |
| Cooper Kupp | Anytime TD Scorer |
Betting Trends & H2H
- These teams split their regular-season series last year. The road team won both of those games.
- Seattle went 6-10-1 against the spread last season.
- San Francisco was 5-12 ATS last season. They were tied for the third-worst record against the spread in the NFL.
49ers vs Seahawks Model Projection
- Score Projection: 49ers 28 – Seahawks 27
- Win Probability: 49ers 58%, Seahawks 42%
Final Thoughts
I think that Sam Darnold is going to fit in well with the Seattle Seahawks’ offense. Seattle is likely to lean on their running game and use that to set up play-action passes and more risk-averse throws to get him into a rhythm. The Seahawks could struggle on defense here, but I like the Seahawks to cover the spread in an exciting game in the Emerald City.
