Green Bay Packers vs Cleveland Browns Prediction – 9/21/2025
The Green Bay Packers will head to Cleveland on Sunday to take on the Cleveland Browns. The Packers are off to a 2-0 start after beating Detroit and Washington, while the Browns have dropped to 0-2 on the season. Early markets have Green Bay favored by over a touchdown in this inter-conference contest. Here, I break down this matchup on the gridiron and give you my Packers vs Browns prediction for Week 3.
Our Packers vs Browns Pick
- Pick: Packers -8.5
- Confidence: 4/5
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Game Snapshot
- Matchup: Green Bay Packers vs Cleveland Browns
- Date & Time: Sunday, September 21, 2025, 1:00 p.m. ET
- Venue: Huntington Bank Field, Cleveland, OH
- Broadcast: FOX
Key Storylines
- The Packers are off to a 2-0 start after their Thursday Night Football victory over the Washington Commanders in Week 2. Green Bay’s defense has allowed 15.5 points per game through two weeks.
- The Packers sacked Jayden Daniels 4 times and consistently collapsed the pocket in their Week 2 win. Micah Parsons has already made an impact getting after the quarterback for Green Bay.
- The Packers have extra time to prepare for this game after playing on Thursday Night Football in their last outing.
- Cleveland is 0-2 after losses to the Cincinnati Bengals and Baltimore Ravens. The offense of the Bengals has struggled with just 16.5 points per game.
Quarterback Play
Jordan Love looks composed and decisive to start the season. He’s sitting at 35 of 53 for 480 yards with four touchdowns and no picks through two games. Love’s spreading targets efficiently to Romeo Doubs, Dontayvion Wicks, and Tucker Kraft while Josh Jacobs keeps defenses honest on early downs. Even with Jayden Reed sidelined, the Packers have shown enough depth to maintain their passing efficiency, especially off play-action.
Cleveland started veteran Joe Flacco in Weeks 1 and 2. He has thrown the ball 45 times in each of his first two starts this season. That is way too much volume for a quarterback like Flacco at this stage in his career. He hasn’t translated all those throws into points and will need to be better on fewer throws for his team to pull an upset here.
Betting Trends & H2H
- Green Bay is 2-0 against the spread to start the season.
- Cleveland is 1-1 against the spread to open their 2025 campaign.
- Green Bay is 0-2 in the over/under market to start this season.
- Cleveland is 1-1 in the totals market through Week 2.
Packers vs Browns Model Projection
Score Projection: Packers 24 – Browns 14
Win Probability: Packers 70%, Browns 30%
Final Thoughts
The Packers are off to a great start this year and the acquisition of Micah Parsons has made their defense one of the best in the league through two weeks. The struggles of Joe Flacco and the Cleveland offense should continue against Green Bay here. I’ll lay the points with the Packers with the expectation that they move to 3-0 both straight up and against the spread.
