The Detroit Lions and Green Bay Packers will meet in Week 1 of the NFL season on Sunday afternoon. This game features two teams that made the playoffs from the NFC North a season ago and is one of the games of the week in the NFL to open the 2025 campaign. Both teams will look to rebound from postseason losses to NFC East teams, and you can get my Lions vs Packers prediction right here before kickoff.
Our Lions vs Packers Pick
- Pick: Detroit Lions +2.5
- Confidence: ★★★★☆
- Get Your Bonus Bets: Click the Claim Bonus button to get our DraftKings Sportsbook bonus – bet $5 and get $300 INSTANTLY and get over $200 off NFL Sunday Ticket!
Bet $5, Get $200 in Bonus Bets Instantly + Over $200 Off NFL Sunday Ticket
Gambling Problem? Call or TEXT 1-800-Gambler 21+ 
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Promo Code: Click To Claim
Bet $5, Get $200 in Bonus Bets Instantly + Over $200 Off NFL Sunday Ticket
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Promo Code: Click To Claim
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Game Snapshot
- Matchup: Detroit Lions vs Green Bay Packers
- Date & Time: Sunday, September 7, 2025, 4:25 PM ET
- Venue: Lambeau Field, Green Bay, WI
- Broadcast: CBS
Lions vs Packers Odds
| Betting Line | Odds |
|---|---|
| Spread | Packers -2.5 |
| Moneyline | Packers -148, Lions +124 |
| Total | 47.5 |
Key Storylines
- Micah Parsons’ Impact: The Packers’ recent trade for Micah Parsons has significantly strengthened their defense. But integrating a new star player this close to the season opener could lead to growing pains. Those growing pains could be especially impactful against a high-octane offense like the one Detroit brings to this game.
- Lions’ Consistency: The Lions have maintained a strong core and are favored to win the NFC North again. Their consistency and depth make them one of the top Super Bowl contenders this year.
- Playoff Responses: Both teams lost to opponents from the NFC East in the playoffs. Green Bay lost to the eventual champion Philadelphia Eagles and the Lions were shocked at home by the Washington Commanders. This is the first chance for both teams to respond to those losses and bettors should take note of body language and other indicators of how they respond.
Quarterback Play
- Jordan Love (Packers): Jordan Love is entering his third season as the Packers’ quarterback. Love has shown flashes of potential but remains inconsistent at times. His performance in this high-stakes opener will be very important to the Packers’ success.
- Jared Goff (Lions): Goff continues to be a steady presence for the Lions. He has a strong supporting cast and a solid offensive line. He will look to silence his critics after laying an egg against Washington in the Divisional playoffs.
Best Player Props
| Player | Prop |
|---|---|
| Jared Goff | Over 1.5 Passing TDs |
| David Montgomery | Anytime Touchdown Scorer |
| Micah Parsons | Under 0.5 Sacks |
Betting Trends & H2H
- Packers’ Home Opener Success: The Packers have won each of their last 12 home openers and have showcased their ability to perform in front of their home crowd.
- Lions’ Road Performance: Detroit has been competitive on the road and their recent form suggests they can challenge the Packers in this matchup.
- Head-to-Head: Detroit won both games between these teams last season and will try to take a third game in a row over their rivals.
Lions vs Packers Model Projection
- Score Projection: Lions 27 – Packers 24
- Win Probability: Lions 53%, Packers 47%
Final Thoughts
I think that bettors should avoid overreacting to the acquisition of Micah Parsons by the Packers. Parsons is undoubtedly one of the best defensive players in the NFL. But it will take some time for him to reach his full potential in a new defensive system. The explosive offense of the Lions should avoid Parsons’ wrath in this game and the Lions are my best bet for this contest as an underdog.
