The Dallas Cowboys will visit the Carolina Panthers in Week 6 of the 2025 NFL season on Sunday. The Cowboys enter this game at 2-2-1 following a blowout win over the New York Jets. They will take on a Panthers team that is 2-3 and looking to stay perfect on their home field for the season. Here, I take a closer look at this matchup and bring you my Cowboys vs Panthers prediction for Week 6.
Our Cowboys vs Panthers Pick
- Pick: Over 49.5
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Dallas Cowboys vs Carolina Panthers
- Date & Time: Sunday, October 12, 2025, 1:00 PM ET
- Venue: Bank of America Stadium, Charlotte, NC
- Broadcast: FOX
Cowboys vs Panthers Odds
| Betting Line | Odds |
|---|---|
| Spread | Cowboys -3.5 |
| Moneyline | Cowboys -185 / Panthers +155 |
| Total | Over/Under 49.5 |
Key Storylines
- Rico Dowdle’s Return: The former Cowboys running back is now with the Panthers. He had a record-setting 206-yard game against the Miami Dolphins in Week 5. He is eager to face his old team and has expressed his intent to challenge Dallas’ defense after a confidence-building week.
- Injuries Impacting Cowboys’ Offense: With key offensive players sidelined, including CeeDee Lamb and KaVontae Turpin, the Cowboys will rely on their depth and the leadership of Dak Prescott to maintain their offensive momentum. They have scored over 35 points three times in five weeks and will try to keep things rolling on offense here.
- Cowboys’ Defensive Questions: Dallas’ defense looked better against the Jets last time out than it did in their 40-40 tie against the Green Bay Packers. But there will always be questions about the Dallas defense based on the way they have played early in the year.
Quarterback Play
Dak Prescott has been a steady presence for the Cowboys, demonstrating efficiency through the air. Despite the absence of key receivers, Prescott ranks second in the league in passing yards and is tied for third with 10 touchdown passes.
Bryce Young has shown potential but remains inconsistent. He made key plays down the stretch to help his team defeat the Miami Dolphins at home in Week 5. But he will need to put up points more consistently over four quarters if he is going to lead his team to another win at home.
Betting Trends & H2H
- Both teams are 3-2 against the spread so far this season.
- Both teams are also 3-2 on over/unders this season, with the majority of their games going over their totals.
- Dallas is 1-2 on the road for the year.
- Carolina is 2-0 on their home field heading into Week 6.
Cowboys vs Panthers Model Projection
- Score Projection: Cowboys 28 – Panthers 24
- Win Probability: Cowboys 60%, Panthers 40%
Final Thoughts
I don’t feel all that strongly about betting a side in this game. This is the second straight road game for the Cowboys, while the Panthers were very fortunate to engineer a comeback win over the struggling Dolphins in Week 5. Instead, I’ll take the over in this contest, as both of these teams have struggled to find their footing on defense.
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