The Arizona Cardinals and New Orleans Saints will do battle in Week 1 of the NFL season on Sunday. The quarterback situations for these teams will be key in this contest. Arizona is looking to get back into the playoffs with Kyler Murray at quarterback and the Saints are trying to figure things out with a young full-time starter. Before kickoff from Caesars Superdome, continue reading to get my Cardinals vs Saints prediction.
Our Cardinals vs Saints Pick
- Pick: Under 42.5
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Arizona Cardinals vs New Orleans Saints
- Date & Time: Sunday, September 7, 2025, 1:00 PM ET
- Venue: Caesars Superdome, New Orleans, LA
- Broadcast: CBS
Cardinals vs Saints Odds
| Spread | Moneyline | Total |
|---|---|---|
| Cardinals –6.5 | Cardinals –285 / Saints +230 | 43.5 |
Key Storylines
- Quarterback Contrast: Kyler Murray leads a Cardinals offense returning almost two-thirds of its 2024 production. Spencer Rattler has been named the Week 1 starter in New Orleans after the departure of Derek Carr.
- Maserati Marv: Marvin Harrison Jr. is back at wide receiver for the Cardinals after a productive rookie campaign. He will be Murray’s top target again this season after scoring eight touchdowns last year.
- Home History: The Saints have won six straight Week 1 home games. But Arizona’s returning veteran core and New Orleans’ quarterback situation makes this a tougher game than usual for them.
Quarterback Play
- Kyler Murray: Kyler Murray is healthy, sharp, and should have chemistry with the group around him going intot his year. The Cardinals averaged 24.7 points per game with him on the field last season.
- Spencer Rattler: Rattler went 0–6 as a starter in 2024. He had a sub-60% completion rate and more picks than touchdowns. Turnover concerns will be a huge factor for him going into his first game as an opening-day starter.
Best Player Props
| Player | Prop |
|---|---|
| Kyler Murray | Over 224.5 Passing Yards |
| James Conner | Under 68.5 Rushing Yards |
| Marvin Harrison Jr. | Anytime TD Scorer |
Betting Trends & H2H
- Arizona is 0–5 ATS in its last 5 road games versus New Orleans.
- The Cardinals are 8–3 ATS in their last 11 games overall.
- These teams have not played a regular season game since 2022. The Cardinals won that game 42-34.
- Arizona went 11-6 against the spread last season.
- New Orleans is 7-10 against the spread a season ago.
Cardinals vs Saints Model Projection
- Score Projection: Arizona Cardinals 24 – New Orleans Saints 16
- Win Probability: Arizona 62%, New Orleans 38%
Final Thoughts
I am concerned about the offense of the Saints going into this season. Spencer Rattler is someone who struggled a season ago and I don’t see him taking a big leap this year. But I do think that New Orleans will make life tough on Kyler Murray as well. Both defenses should win the day in this game and I think that the under is the way to go in this Week 1 NFC matchup from New Orleans.
