San Diego Padres vs Seattle Mariners Prediction – 8/25/2025
The San Diego Padres will head to T-Mobile Park to face the Seattle Mariners on Monday night. Both teams are in playoff positions heading into this huge series opener in the Pacific Northwest. They will look to set the tone in this interleague game. Before the first pitch from Seattle, you can keep reading to get my Padres vs Mariners prediction for the night.
Our Padres vs Mariners Pick
- Pick: Over 8.5
- Confidence: 3/5
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Game Snapshot
- Matchup: San Diego Padres vs Seattle Mariners
- Date & Time: Monday, August 25, 2025, 9:40 p.m. ET
- Starting Pitchers: J.P. Sears (SD) vs Bryce Miller (SEA)
- Stadium: T-Mobile Park, Seattle, WA
- Broadcast: ROOT Sports NW and SDPA
Key Storylines
Pitching matchup
San Diego will go with J.P. Sears on the mound tonight. Sears is 8-10 with a 4.94 ERA and will look to improve on those numbers to help his team get a key victory tonight. Seattle starts Bryce Miller. Miller has struggled with a 2-5 record and a 5.87 ERA. He will have to navigate carefully against the dangerous lineup of the Padres in this game.
Key Players
- Padres: Manny Machado and Fernando Tatis Jr. will be vital to San Diego’s success in this series against the Mariners.
- Mariners: Cal Raleigh is up to 49 home runs this season and his year has been one of the best by a catcher in the history of baseball.
Recent team streaks
The Padres had a five-game winning streak snapped by the Los Angeles Dodgers on Sunday. The Mariners won two out of three games against the Athletics over the weekend.
Best Player Props
| Category | Player | Prop |
|---|---|---|
| Home runs | Cal Raleigh | Over 0.5 |
| Strikeouts | J.P. Sears | Over 4.5 |
| Total bases | Manny Machado | Over 1.5 |
Betting Trends & H2H
- The Mariners hold a 3-0 lead in the season series against the Padres.
- Seattle went 3-0 against the Padres in San Diego and will host the Padres for the first time tonight.
- All three games in that first series between San Diego and Seattle had seven runs or fewer.
Padres vs Mariners Model Projection
Score Projection: Mariners 5 – Padres 4
Win Probability: Mariners 52%, Padres 48%
Final Thoughts
This is going to be a close game in either direction and could be the best of the night in baseball. The key will be timely hitting and which team can find it in high-leverage situations. I’d lean toward the Mariners to be that team. But I prefer the over as the best bet for this game, as both offenses are operating at a high level and should do some early damage against struggling starting pitchers.
