Pittsburgh Pirates vs Baltimore Orioles Prediction – 9/10/2025

The Pittsburgh Pirates and Baltimore Orioles will play in the second game of a three-game series on Wednesday. The Orioles won the first game of this series in extra innings and Pittsburgh will try to even things at a game apiece with ace Paul Skenes on the mound. Here, I weigh whether Skenes’ presence is enough for the Pirates to get the win in this game as I make my Pirates vs Orioles prediction for this matchup.

Our Pirates vs Orioles Pick

• Pick: Pirates moneyline
• Confidence: 3/5
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4.5/5

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Game Snapshot

• Matchup: Pittsburgh Pirates vs Baltimore Orioles
• Date & Time: Wednesday, September 10, 6:35 PM ET
• Starting Pitchers: Paul Skenes vs Tyler Wells
• Stadium: Oriole Park at Camden Yards, Baltimore, MD
• Broadcast: MASN, SportsNet Pittsburgh

Key Storylines

• Paul Skenes is set to take the mound for the Pirates in this game. Skenes is deserving of the NL Cy Young award this season but issues with run support have prevented him from stacking up wins. Skenes will need some run support if he is going to help the Pirates end their losing streak.
• Baltimore is playing some excellent baseball of late. They won back-to-back series against the San Diego Padres and LA Dodgers coming into this three-game set. They won the first game of this series in extra innings over the Pirates and Baltimore will attempt to continue their winning ways here.

Pitching matchup

• Paul Skenes: Pittsburgh’s Paul Skenes is arguably the best pitcher in baseball. He is 10-9 with a 1.98 ERA and a 0.94 WHIP. Skenes has 195 strikeouts in 173 innings of work and the Orioles will have their work cut out for them against Skenes here.
• Tyler Wells: Wells is back from UCL surgery and won his season debut on September 2 at San Diego. He pitched five innings with four strikeouts, no walks, and two earned runs allowed. He will likely be on a pitch count early in his return. That will shift more of the burden onto Baltimore’s bullpen.

Recent team streaks

• Pittsburgh has lost four games in a row coming into this game on Wednesday.
• Baltimore has won four of its last five games and are back to 10 games under .500 for the year.

Best Player Props

Betting Trends & H2H

• The Orioles took a 1-0 lead in the season series with Pittsburgh on Tuesday night.
• Pittsburgh is 22-48 on the road for the season.
• Baltimore improved to 34-38 at home with their win over the Pirates in the series opener.

Pirates vs Orioles Model Projection

Score Projection: Pirates 4 – Orioles 3

Win Probability: Pirates 52%, Orioles 48%

Final Thoughts

I am going to back the Pittsburgh Pirates to win on the road on Wednesday night. Skenes will give the Pirates a great chance to take a lead into the late innings here. I expect the Pirates to avoid faltering in the late innings this time around and for Pittsburgh to end its four-game losing streak.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.