Philadelphia Phillies vs Los Angeles Dodgers Prediction – 9/16/2025

The Philadelphia Phillies and Los Angeles Dodgers will meet on Tuesday night in a battle of two National League heavyweights. Both teams are leading their respective divisions and are playing for postseason seeding over the final couple of weeks of the regular season. Philadelphia won the first matchup in this series on Monday night and will look for a similar result tonight. Here, I take a closer look at this matchup and make my Phillies vs Dodgers prediction for Tuesday.

Our Phillies vs Dodgers Pick

  • Pick: Dodgers moneyline
  • Confidence: 3/5
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Game Snapshot

  • Head-to-head: Philadelphia Phillies at Los Angeles Dodgers
  • Date and time: Wednesday, September 17, 2025, 10:10 PM ET
  • Starting Pitchers: Cristopher Sanchez vs Shohei Ohtani
  • Stadium: Dodger Stadium, Los Angeles, CA
  • Broadcast: TBS

Starting Pitchers

  • The Phillies will go with Cristopher Sanchez on the mound on Tuesday night. Sanchez is 13-5 with a 2.57 ERA for the season. He has picked up the win in each of his last two starts. That includes a six-inning outing against the New York Mets where he allowed just one run.
  • Shohei Ohtani will take the hill for the Dodgers in this contest. Ohtani is 1-1 with a 3.75 ERA in limited action on the mound. He has yet to pitch over five innings in a game yet this season and that lack of longevity on the hill could make a difference in this game.

Key Storylines

  • Division races and seeding are factors for both teams late in the season. Philadelphia is closing in on the NL East crown, while LA leads the NL West and continues to chase top postseason positioning.
  • Superstar power: Kyle Schwarber sits at 53 home runs after another huge week. Shohei Ohtani has 49 homers and continues to headline an LA offense that is one of the best in baseball.
  • Injuries: Trea Turner and Alec Bohm are on the injured list for Philadelphia, thinning the infield and top-of-order. Zack Wheeler is out long term, placing even more pressure on Sánchez to perform.

Recent team streaks

  • The Phillies won the first game of this series in extra innings and they have won four of their last five games.
  • The Dodgers have won two of their last three games and had a two-game winning streak snapped on Monday night.

Best Player Props

Prop typePlayerPick
Home runKyle SchwarberOver 0.5
Home runShohei OhtaniOver 0.5
StrikeoutsShohei OhtaniUnder 5.5
StrikeoutsCristopher SanchezOver 5.5
Total basesFreddie FreemanOver 1.5
  • Philadelphia leads the season series 3-1 against the Dodgers this year.
  • The Phillies won the last two games between these teams.

Phillies vs Dodgers Model Projection

Score Projection: Phillies 3 – Dodgers 4

Win Probability: Phillies 44%, Dodgers 56%

Final Thoughts

We should be in for another close game between these elite National League teams. Three of the four games between these teams have been decided by one run so far this season. I think we will see another one-run game tonight and I’ll take the Dodgers to win it behind a strong start from Ohtani.


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Home MLB Picks Philadelphia Phillies vs Los Angeles Dodgers Prediction – 9/16/2025