Philadelphia Phillies vs Chicago White Sox Pick – 7/28/2025

The Philadelphia Phillies enter Monday’s matchup against the Chicago White Sox as heavy favorites. That isn’t a surprise given the difference in the records between the two teams. But the White Sox do have some talent in their lineup that could surprise the Phillies if they aren’t careful. Continue reading to get my Phillies vs White Sox prediction for this interleague series opener.

Our Phillies vs White Sox Pick

  • Pick: White Sox +1.5
  • Confidence: 4 stars
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Game Snapshot

  • Matchup: Philadelphia Phillies vs Chicago White Sox
  • Date & Time: Monday, July 28, 2025, 7:40 PM ET
  • Starting Pitchers: Cristopher Sánchez (PHI) vs Davis Martin (CWS)
  • Stadium: Guaranteed Rate Field, Chicago, IL
  • Broadcast: CHSN, NBCS-PH

Key Storylines

Pitching Matchup

Cristopher Sánchez has been exceptional this season. He enters this game with an impressive 9-2 record and a 2.40 ERA. He has allowed no more than one earned run in his last six starts. Chicago’s Davis Martin has struggled this year. He has a 2-8 record with a 3.89 ERA. His recent performance includes a loss where he gave up four runs in five innings against Tampa Bay. While he has not done enough individually to rack up wins, I think some of that can be attributed to the team around him as well.

Key Players

  • Philadelphia Phillies: Kyle Schwarber leads the team with 36 home runs and 84 RBI. He provides the power for this Phillies team. Trea Turner offers consistency with a team-best .293 batting average.
  • Chicago White Sox: Lenyn Sosa leads the White Sox with a .264 batting average. Andrew Benintendi has 13 home runs and 42 RBI. He serves as the primary power source in the lineup.

Recent Team Streaks

  • Philadelphia Phillies: The Phillies have won two of their last three games.
  • Chicago White Sox: Chicago has lost two straight to the Chicago Cubs entering this series.

Best Player Props

PlayerProp
Kyle SchwarberOver 0.5 Home Runs
Trea TurnerOver 1.5 Total Bases
Lenyn SosaOver 0.5 Home Runs
  • This is the first time these two teams will play this year.
  • The Phillies are 27-26 on the road in 2025.
  • Chicago is 22-31 at home for the season.

Phillies vs White Sox Model Projection

  • Score Projection: Phillies 5 – White Sox 4
  • Win Probability: Phillies 68%, White Sox 32%

Final Thoughts

The Phillies should come away with the win in this interleague series opener. But I think it will be closer than the betting odds suggest. Davis Martin has not been as bad as his record would imply and he should keep the White Sox competitive in this game. I’ll take the White Sox to cover the runline as an underdog in this game.


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Home MLB Picks Philadelphia Phillies vs Chicago White Sox Pick – 7/28/2025