Los Angeles Dodgers vs San Francisco Giants Prediction – 9/12/2025
The Los Angeles Dodgers and San Francisco Giants will meet on Friday night in the Bay Area. These two storied rivals will collide in a huge game for both sides. The Dodgers are trying to hold onto the lead in the NL West and the Giants are in the thick of the NL Wild Card race. Here, I break down this massive matchup in the National League playoff picture and give you my Dodgers vs Giants prediction.
Our Dodgers vs Giants Pick
- Pick: Dodgers moneyline
- Confidence: 3/5
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Game Snapshot
- Matchup: Los Angeles Dodgers vs San Francisco Giants
- Date and Time: Friday, September 12, 2025, 10:15 PM ET
- Starting Pitchers: Yoshinobu Yamamoto vs Justin Verlander
- Stadium: Oracle Park, San Francisco, CA
- Broadcast: MLB Network
Key Storylines
- The LA Dodgers come into this game with a 2.5-game lead over the San Diego Padres in the race for the NL West title. LA needs to keep winning to avoid letting the Padres catch up to them in the division title race.
- San Francisco enters this game just 1.5 games back of the final Wild Card spot in the National League. The New York Mets are in a freefall right now and the Giants have a huge opportunity to get into playoff position if they can perform well in this weekend’s series.
Pitching matchup
The pitching matchup in this game is nothing short of box office. Yoshinobu Yamamoto will take the mound in this matchup for the Dodgers. Yamamoto is 11-8 on the season and has a 2.72 ERA. He could both help his team’s division title hopes and hurt the playoff hopes of a rival with a strong start here. Justin Verlander is on the opposite side of this pitching matchup. Verlander is just 3-10 and has looked past his prime this year. But he is always capable of turning back the clock.
Recent team streaks
- The Dodgers have a four-game winning streak going into this matchup.
- San Francisco had a two-game winning streak snapped last time out against the Arizona Diamondbacks.
Best Player Props
| Player | Prop Type | Recommendation |
|---|---|---|
| Shohei Ohtani | Home run | Over 0.5 |
| Yoshinobu Yamamoto | Strikeouts | Over 5.5 |
| Willy Adames | Total bases | Under 1.5 |
Betting Trends & H2H
- The Dodgers hold a 4-2 advantage in the season series against the Giants.
- This is the first of seven games between these teams scheduled over the next 10 days. It is a huge stretch for both teams.
Dodgers vs Giants Model Projection
Score Projection: Dodgers 4 – Giants 3
Win Probability: Dodgers 58%, Giants 42%
Final Thoughts
This is the most important stretch of the season for both teams and they will get very familiar with each other over the next 10 days. I think the first game of this stretch will go the way of the Dodgers. Los Angeles has a better starting pitcher and a better offense in this contest and that should help them to get a huge win on the road.
