The Milwaukee Brewers will host the Los Angeles Angels in an interleague matchup on Thursday night. The Brewers are on the verge of clinching the NL Central title, while the Los Angeles Angels are looking to end a six-game losing streak. Here, I break down the final game of their three-game series and bring you my Angels vs Brewers prediction for Thursday’s game.
Our Angels vs Brewers Pick
- Pick: Brewers -1.5
- Confidence: 4/5
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Game Snapshot
- Matchup: Los Angeles Angels vs Milwaukee Brewers
- Date & Time: Thursday, September 18, 2025, 7:40 PM ET
- Starting Pitchers: Yusei Kikuchi (LAA) vs Quinn Priester (MIL)
- Stadium: American Family Field, Milwaukee, WI
- Broadcast: MLB.tv
Key Storylines
Pitching Matchup
Yusei Kikuchi (6-11, 4.08 ERA) takes the mound for the Angels, aiming to halt their losing streak. Kikuchi has struggled on the road this season. He enters this game with a 3-7 record and a 4.50 ERA away from home. Opposing Kikuchi is Quinn Priester (13-2, 3.25 ERA), who has been a standout for the Brewers. Priester leads the NL in wins and has been particularly effective at home. He has a 9-1 record and a 2.80 ERA at home for the year.
Key Players
- Angels: Taylor Ward has been the team’s offensive bright spot, hitting two solo home runs in the previous game to bring his season total to 33. He has reached 100 RBI for the season.
- Brewers: Blake Perkins delivered a five-RBI performance in the series opener. Sal Frelick added a three-run homer, showcasing the depth of Milwaukee’s lineup. They will join the stars of the Brewers as important contributors in this contest.
Recent Team Streaks
- Angels: The Angels are on a six-game losing streak. They have a 3-7 record in their last 10 games.
- Brewers: Milwaukee has won two straight games. They have a 6-4 record in their last 10 games.
Best Player Props
| Player | Stat | Over/Under |
|---|---|---|
| Yusei Kikuchi | Strikeouts | Under 5.5 |
| Quinn Priester | Strikeouts | Over 6.5 |
| Christian Yelich | Home Runs | Over 0.5 |
Betting Trends & H2H
- The Brewers are 2-0 against the Angels so far this season.
- Both of the previous games between these teams ended with Milwaukee winning 9-2.
- The over has cashed in both of the games played by these teams in 2025.
- This is the final regular-season meeting between these interleague opponents.
Angels vs Brewers Model Projection
- Score Projection: Angels 3 – Brewers 5
- Win Probability: Angels 35%, Brewers 65%
Final Thoughts
With Quinn Priester’s dominant track record at home and the Brewers’ overall momentum, they are likely to complete the series sweep of the Angels tonight. The Angels’ struggles, particularly on the road, make them tough to back in this matchup. Betting on the Brewers to cover the -1.5 spread offers value, given their current form and pitching advantage against an opponent that is sputtering to the finish line late in the season.
