Chicago White Sox vs Minnesota Twins Pick – 9/1/2025
The Minnesota Twins and Chicago White Sox will open a four-game series from Target Field on Monday afternoon. These teams have both had disappointing seasons so far and will look for a win over one another here. Minnesota enters as the betting favorite but this game could go either way. Before the action begins in Minneapolis, continue reading to get my White Sox vs Twins prediction.
Our White Sox vs Twins Pick
- Pick: Over 8.5 total runs
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Chicago White Sox vs Minnesota Twins
- Date & Time: Monday, September 1, 2025, 2:10 p.m. ET
- Starting Pitchers: Undecided (White Sox) vs Bailey Ober (Twins)
- Stadium: Target Field, Minneapolis, MN
- Broadcast: MNNT and CHSN
Key Storylines
Pitching matchup
Bailey Ober of Minnesota stands at 4-7 with an ERA of 5.14. Ober has given up 135 hits in 119 innings of work. He will look to take advantage of this matchup against a White Sox team that has struggled to score runs on a consistent basis throughout the season. Chicago has yet to decide on a starting pitcher for this game and that decision will be something bettors should monitor before first pitch in this contest.
Key Players
Byron Buxton has been hot for the Twins. He enters the game on a two-game home run streak and is leading the team with 29 home runs and 70 RBI. Lenyn Sosa leads the White Sox offensively with 17 long balls and 61 RBI. The Twins lineup features steady contributors like Trevor Larnach, Brooks Lee, and Matt Wallner in addition to Buxton.
Recent team streaks
Chicago has fallen short recently with just one win in its last five games. Minnesota has taken three of its last five games and won its last series against the San Diego Padres. Totals involving both teams have frequently exceeded run projections. The Twins’ last five games have all gone over.
Best Player Props
| Player | Prop |
|---|---|
| Byron Buxton | Over 0.5 Home Runs |
| Lenyn Sosa | Over 1.5 Total Bases |
| Bailey Ober | Under 5.5 Strikeouts |
Betting Trends & H2H
- The Twins hold a 5-4 lead in their season series against the White Sox.
- Chicago has won their last two games against Minnesota.
- Minnesota is 18-23 against AL Central opponents so far this year.
- Chicago is 12-30 against division opponents in 2025.
White Sox vs Twins Model Projection
Score Projection: Twins 6 – White Sox 4
Win Probability: Twins 63%, White Sox 37%
Final Thoughts
Bettors may want to wait until they find out who is starting this game on the mound for Chicago before locking in any bets. But I think that this game will go over the total no matter who ends up getting the start for the White Sox. Bailey Ober has not been convincing on the mound at all for Minnesota and the Twins should put up their share of runs as well.
