The Delaware Fightin’ Blue Hens will travel to Boulder to face the Colorado Buffaloes on Saturday afternoon. This is the second game as an FBS football program for Delaware and they will look to pull of a huge upset over Deion Sanders’ Buffaloes here. Before kickoff in this interesting college football matchup, continue reading to get my Delaware vs Colorado prediction.
Our Delaware vs Colorado Pick
- Pick: Colorado Buffaloes -23.5
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Delaware Fightin’ Blue Hens vs Colorado Buffaloes
- Date & Time: Saturday, September 6, 2025, 3:30 PM ET
- Venue: Folsom Field, Boulder, CO
- Broadcast: FOX
Delaware vs Colorado Odds
| Spread | Moneyline | Total |
|---|---|---|
| Colorado -23.5 | Colorado -3000 / Delaware +1100 | 50.5 |
Key Storylines
- Delaware’s Transition to FBS: This season marks Delaware’s first year in Conference USA after moving up from the FCS level. They beat up on FCS Delaware State in their season opener but this will be their first test against an FBS opponent as a member of this level of competition.
- Colorado’s Offensive Adjustments: Colorado’s coaching staff will look to refine their offensive schemes to better utilize their talent after a disappointing showing against Georgia Tech. The Buffaloes were held to 20 points and foreshadowed some growing pains with new quarterback Kaidon Salter. They will try to bounce back against a lesser opponent this week.
Quarterback Play
Delaware: Quarterback Nick Minicucci led the Blue Hens to a 35-17 victory over Delaware State in their opener. He completed 28 of his 36 passes for 251 yards and three touchdowns. His performance is not expected to be as good this week against an FBS opponent in the Buffs.
Colorado: Buffaloes quarterback Kaidon Salter threw for 159 yards and a touchdown in the Buffaloes’ 27-20 loss to Georgia Tech. Salter’s ability to connect with his receivers and manage the game will be key to Colorado’s success. His ability to break the pocket and run was also a factor against the Yellow Jackets. He ran 13 times for 43 yards in his first game as Colorado’s quarterback.
Betting Trends & H2H
- Both teams failed to cover the spread in their first game of the season.
- Both teams went under the total in their season openers.
- This will be the first-ever meeting between Delaware and Colorado in college football.
Delaware vs Colorado Model Projection
Score Projection: Delaware 14 – Colorado 41
Win Probability: Delaware 6.5%, Colorado 93.5%
Final Thoughts
Colorado should have no problem bouncing back from their season-opening loss to Georgia Tech by getting a win here. Kaidon Salter looked mediocre against a quality opponent and should look very good again when he faces a new FBS team this week. Salter was great against bad teams with Liberty and I expect a similar showing from him against Delaware. I’ll lay the big number with Colorado here as they should get back to the .500 mark for the 2025 season.
