The Minnesota Timberwolves and Los Angeles Lakers will meet in the NBA on Friday night. The Wolves got a win in their season opener and they will look for a second straight victory over a Lakers team that dropped their season opener at home a few nights ago. Before this matchup from Los Angeles begins, continue reading to get my Timberwolves vs Lakers prediction.
Our Timberwolves vs Lakers Pick
- Pick: Timberwolves -2.5
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Minnesota Timberwolves @ Los Angeles Lakers
- Date & Time: Friday, October 24, 2025, 10:00 PM ET
- Venue: Crypto.com Arena, Los Angeles, CA
- Broadcast: Prime Video
Key Storylines
- The Timberwolves enter the game with a 1-0 record, having secured a 118-114 victory over the Portland Trail Blazers in their season opener. Minnesota has a significant health advantage going into this game and they will try to take advantage of that to move to 2-0 on the year.
- The Lakers are 0-1 after a 119-109 loss to the Golden State Warriors, despite a standout performance from Luka Dončić. Doncic recorded 43 points, 12 rebounds, and nine assists. But the absence of LeBron James has put a burden on role players to perform like stars.
- James remains sidelined due to sciatica, leaving the Lakers without one of their star players for the time being.
Head-to-Head & Betting Trends
- The Timberwolves have won each of their last 10 games as favorites against the Lakers following a win.
- The Lakers have lost each of their last four games against Western Conference opponents.
- These teams are both 0-1 against the spread going into this game.
- The Lakers and Timberwolves both went over the total in their first games of the year.
Best Player Props to Watch
| Player | Prop |
|---|---|
| Anthony Edwards | Over 25.5 Points |
| Luka Dončić | Over 10.5 Assists |
| Deandre Ayton | Over 8.5 Rebounds |
Timberwolves vs Lakers Model Projection
- Score Projection: Timberwolves 118 – Lakers 110
- Win Probability: Timberwolves 55%, Lakers 45%
Final Thoughts
The Lakers are in a rough spot early in the season. They are without LeBron James and that has forced them to put all of their eggs into the basket of Luka Doncic. We saw that the Lakers can even get a huge game out of Concic and still lose in their season opener. I am expecting something similar to happen in this game. I recommend laying the points with the Timberwolves, as they should win their second road game in a row to get off to an impressive 2-0 start.
