Washington Nationals vs St. Louis Cardinals Pick – 7/10/2025

The Washington Nationals and St. Louis Cardinals split the first two games of their three-game series. They will face off in the rubber match on Thursday. Both teams could have plenty of scoring chances in this game thanks to the starting pitching matchup. Here, we take a closer look at the pitchers and everything else you need to know about this matchup, including our Nationals vs Cardinals prediction.

Our Nationals vs Cardinals Pick

• Pick: St. Louis Cardinals Moneyline
• Confidence: ★★★
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4.8/5

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Game Snapshot

• Matchup: Washington Nationals at St. Louis Cardinals
• Date & Time: Thursday, July 10, 2025, 7:45 PM EDT
• Starting Pitchers: Michael Soroka vs Miles Mikolas
• Stadium: Busch Stadium, St. Louis, MO
• Broadcast: FDSMW and MASN

Key Storylines

• Both starting pitchers have an ERA over 5.00 for the season. Miles Mikolas and Michael Soroka are both vulnerable to contact and which pitcher is sharper could decide this game.
• The Cardinals enter this game at 5.5 games back of the Chicago Cubs in the NL Central. Beating last place teams like the Nationals is crucial to their aspirations for this season.

Bullpen usage

Washington’s bullpen has the worst ERA among relief pitchers in the league. But the Nationals haven’t been bad in relief in this series yet. If the Cardinals can get to the Nationals’ bullpen in this game, they could snag this series once and for all.

Recent team streaks

• The Cardinals are 1-4 in their last five games and snapped their losing streak on Wednesday.
• The Nationals are 2-3 in their last five games.

Betting Trends & H2H

• The Cardinals lead the season series between these teams by a 4-1 margin.
• The Nationals are 25-28 at night this season. St. Louis is 26-23 in night games.
• The Cardinals are 27-18 at home for the year. The Nationals are 20-26 on the road.

Nationals vs Cardinals Model Projection

Score Projection: Washington Nationals 2 – St. Louis Cardinals 5

Win Probability: Washington Nationals 38%, St. Louis Cardinals 62%

Final Thoughts

This game feels like a bounce-back spot for the Cardinals to me. They should get into the Nationals’ bullpen relatively early against a struggling starter in Soroka. From there, I expect the Cardinals to do some scoring against the worst bullpen in the league. Expect the Cardinals to win this game and cover the runline as a favorite at home.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.