Tampa Bay Rays vs Chicago White Sox Pick – 9/10/2025

The Tampa Bay Rays will face the Chicago White Sox on Wednesday night at Rate Field. The Rays won the first game of this series on the road to get back to the .500 mark on the season. They will try to get above .500 with another win over one of the worst teams in baseball tonight. Continue reading to get info on the pitching matchup, betting trends, and more as I bring you my Rays vs White Sox prediction.

Our Rays vs White Sox Pick

  • Pick: White Sox Moneyline
  • Confidence: 4/5
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Game Snapshot

  • Matchup: Tampa Bay Rays vs Chicago White Sox
  • Date & Time: Wednesday, September 10, 2025, 7:40 PM ET
  • Starting Pitchers: Griffin Jax (Rays) vs Undecided (White Sox)
  • Stadium: Rate Field, Chicago, IL
  • Broadcast: CHSN in Chicago, FDSN Sun in Tampa Bay

Key Storylines

  • The pitching matchup in this game is going to be very interesting. It is a bullpen day for the Rays and the White Sox have yet to decide on a starting pitcher. Both teams will have to navigate an unusual situation to win this game.
  • Tampa has a chance to get back above the .500 mark for the season with a win here. Tampa is 4.5 games back of the final AL Wild Card spot and would need to leapfrog several teams to get there. But they could inch closer with a win here.

Pitching matchup

The Rays are going with an opener out of the bullpen to begin this contest. That opener will be Griffin Jax. Jax is 1-7 this season with a 4.81 ERA. This is an interesting spot for Jax, who has had terrible luck in the loss column this year. But he has a chance to get his team off to a good start in this matchup.

Chicago has not decided on a starting pitcher in this game as of this writing. They could also go with a bullpen day today. Whether they do that or go with a spot starter, they will need to perform at a high level to set a positive tone going into the rest of the game.

Recent team streaks

  • The Rays ended a three-game losing streak with Tuesday’s win over the White Sox.
  • Chicago has dropped two of its last three games entering Wednesday night.

Best Player Props

PlayerProp TypeRecommendation
Junior CamineroTotal basesUnder 1.5
Yandy DíazTotal basesOver 1.5
Lenyn SosaTotal basesOver 1.5
  • The season series between these teams is tied 2-2 going into this contest.
  • Road teams are 3-1 in the four games these teams have played so far this season.

Rays vs White Sox Model Projection

Score Projection: White Sox 5 – Rays 3

Win Probability: Rays 50%, White Sox 50%

Final Thoughts

This is an interesting game from a betting standpoint as we don’t know who is pitching for the bulk of this game on either side. I’m going to take the underdog White Sox at home, as I have this game as a toss-up given the pitching situation on both sides.


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Home MLB Picks Tampa Bay Rays vs Chicago White Sox Pick – 9/10/2025