St. Louis Cardinals vs Seattle Mariners Prediction – 9/10/2025
The St. Louis Cardinals and Seattle Mariners will face off on Wednesday. Playoff positions are at stake in this game for Seattle as they fight for the AL West championship as well as a Wild Card spot. St. Louis is holding onto some fading Wild Card hopes as well and will try to get a win that they desperately need. Here, I break down this interleague matchup and give you my Cardinals vs Mariners prediction from the Pacific Northwest.
Our Cardinals vs Mariners Pick
- Pick: Mariners -1.5
- Confidence: 4/5
- Wednesday MLB Bonus Bets: Use our DraftKings Sportsbook bonus to turn a $5 into $200 in bonus bets INSTANTLY. Just hit the Claim Bonus button to get started!
Bet $5, Get $200 in Bonus Bets Instantly + Over $200 Off NFL Sunday Ticket
Gambling Problem? Call or TEXT 1-800-Gambler 21+ 
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Promo Code: Click To Claim
Bet $5, Get $200 in Bonus Bets Instantly + Over $200 Off NFL Sunday Ticket
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Promo Code: Click To Claim
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Game Snapshot
- Matchup: St. Louis Cardinals vs Seattle Mariners
- Date & Time: Wednesday, September 10, 9:40 PM ET
- Starting Pitchers: Michael McGreevy vs Logan Gilbert
- Stadium: T-Mobile Park, Seattle, WA
- Broadcast: ROOT Sports Northwest in Seattle, FanDuel Sports Network Midwest in St. Louis
Key Storylines
- The Mariners are within one game of the Houston Astros in the AL West standings going into this matchup. They are also in the third Wild Card spot in the American League. Securing a sweep with a win here would be huge for their playoff hopes on multiple fronts.
- St. Louis is 4.5 games back of the final NL Wild Card spot. It would take a lot of winning and a lot of help for St. Louis to get into the playoffs from this position. But they will try to do that starting with a win tonight.
Pitching matchup
Logan Gilbert has been the model of efficiency at home going into this start at home. He has a sub-1.05 WHIP this year with a fastball that holds velocity deep into games. His recent form has trended up and he matches up well against a Cardinals lineup that ranks near league average in contact quality. Expect Gilbert to lean on his four-seam fastball and slider early.
Michael McGreevy is a pitcher who pitches to contact. He has just 43 strikeouts in 73 innings going into this start. He is 6-3 with a 4.68 ERA going into this contest and he will need to step his game up to keep up with Gilbert and help his team to get a win in this important contest.
Recent team streaks
- The Cardinals have lost two consecutive games to the Mariners entering this contest.
- Seattle has won four games in a row and could move into a tie with the Astros for the AL West lead with another win tonight.
Best Player Props
| Player | Market | Pick |
|---|---|---|
| Logan Gilbert | Strikeouts | Over 6.5 |
| Michael McGreevy | Strikeouts | Under 4.5 |
| Cal Raleigh | Home Run | Over 0.5 |
| Julio Rodríguez | Total Bases | Over 1.5 |
| Brendan Donovan | Total Bases | Over 1.5 |
Betting Trends & H2H
- The Mariners are 2-0 against the Cardinals so far this season.
- Seattle has won both of their games against the Cardinals by two runs.
Cardinals vs Mariners Model Projection
Score Projection: Cardinals 2 – Mariners 4
Win Probability: Cardinals 38%, Mariners 62%
Final Thoughts
The Mariners have covered the runline in each of the first two games of this series. I expect them to do the same in this contest, thanks to the solid starting pitching of Logan Gilbert, who will keep the pressure on the Astros with another win tonight.
