St. Louis Cardinals vs San Diego Padres Prediction – 8/2/2025
The St. Louis Cardinals will face the San Diego Padres at Petco Park on Saturday night. The Padres have been in solid form and have won six straight games. The Cardinals have struggled and are looking to keep themselves afloat in the NL Wild Card race. The Padres are the favorites and you can continue reading to get my Cardinals vs Padres prediction for this late night matchup from San Diego.
Our Cardinals vs Padres Pick
- Pick: Padres -1.5
- Confidence: 4 stars
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Game Snapshot
- Matchup: St. Louis Cardinals vs San Diego Padres
- Date & Time: Saturday, August 2, 2025, 10:10 PM ET
- Starting Pitchers: Michael McGreevy (STL) vs Randy Vásquez (SD)
- Stadium: Petco Park, San Diego, CA
- Broadcast: SDPA and FDSMW
Key Storylines
Pitching Matchup
- Michael McGreevy (STL): Michael McGreevy has a 2-2 record with a 4.91 ERA and 1.21 WHIP this season. He has shown flashes of potential but has struggled with consistency. He will look to lead his team to a much-needed win tonight.
- Randy Vásquez (SD): San Diego’s Randy Vásquez holds a 3-4 record with a 3.65 ERA and 1.37 WHIP. He has been more effective at home than he has been on the road and will look to continue that trend in this matchup.
Key Players
- Willson Contreras (STL): Contreras leads the Cardinals with 15 home runs and 62 RBI. He will need to take advantage of his opportunities against Vasquez early in this game.
- Manny Machado (SD): Machado is hitting .302 with 20 home runs and 71 RBI. He leads the Padres in all three of those offensive categories.
Recent Team Streaks
- Padres: The Padres enter this contest on a six-game winning streak.
- Cardinals: The Cardinals have lost three straight games and have suffered four losses in their last five.
Best Player Props
| Player | Prop |
|---|---|
| Willson Contreras | Over 0.5 Home Runs |
| Manny Machado | Over 0.5 Home Runs |
| Randy Vásquez | Over 5.5 Strikeouts |
Betting Trends & H2H
- The Padres hold a 3-2 lead in the season series against the Cardinals.
- San Diego has won three games in a row after dropping their first two games against the Cardinals.
Cardinals vs Padres Model Projection
- Score Projection: Padres 4 – Cardinals 3
- Win Probability: Padres 55%, Cardinals 45%
Final Thoughts
The Padres enter this game with all of the momentum. With a favorable pitching matchup and a stronger bullpen, I think the Padres are well-positioned to extend their winning streak here. I will bet the Padres to win this game on the moneyline and to prolong the struggles of the Cardinals in this contest.
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