St. Louis Cardinals vs Milwaukee Brewers Pick – 9/14/2025
The St. Louis Cardinals will face the Milwaukee Brewers at American Family Field in Milwaukee on Sunday afternoon. The Brewers come into this game with the best record in baseball and they will look to move a step closer to locking up home-field advantage in the playoffs with a win here. Can Milwaukee win on Sunday to secure a three-game sweep? Continue reading to get my Cardinals vs Brewers prediction for Sunday.
Our Cardinals vs Brewers Pick
- Pick: Brewers -1.5
- Confidence: 4/5
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Game Snapshot
- Matchup: St. Louis Cardinals vs Milwaukee Brewers
- Date & Time: Sunday, September 14, 2025, 2:10 p.m. ET
- Starting Pitchers: Miles Mikolas vs José Quintana
- Stadium: American Family Field, Milwaukee, WI
- Broadcast: MLB.tv
Key Storylines
- Milwaukee entered the weekend off a 3-game sweep in Arlington at the hands of the Texas Rangers. But they have bounced back nicely to start this series with two wins in a row.
- St. Louis welcomed Alec Burleson back this week. He leads the team in batting average and homered in his first game back in Seattle.
- Willson Contreras is active after a brief suspension. He remains the Cards’ top power producer with 20 HR and 79 RBI.
- St. Louis enters this game 3.5 games back of the final NL Wild Card spot. Milwaukee has a six-game lead in the NL Central standings. This is a game with playoff implications for both teams.
Pitching matchup
- Miles Mikolas, RHP, Cardinals: 7-10, 4.84 ERA, 1.32 WHIP. Mikolas pitches to contact and the home run ball has bitten him. Earlier this month, he went five strong innings in Seattle before the pen unraveled. Against MIL this season, he has shown competitiveness, including seven strikeouts over six innings in June at this park. But power damage is the risk in a homer-friendly building.
- José Quintana, LHP, Brewers: 11-6, 3.88 ERA, 1.28 WHIP. Quintana is a veteran lefty who has stabilized the Milwaukee rotation. He has strung together quality work and recently held Texas in check early before the bullpen faltered later in that game. Quintana’s track record against the Cardinals is extensive and generally positive. American Family Field has not bothered him thanks to command and soft contact rates.
Recent team streaks
- The Brewers have won two games in a row going into the final game of this series.
- St. Louis has lost five straight games and needs to turn things down in a hurry.
Best Player Props
| Market | Pick |
|---|---|
| Home run | Christian Yelich Over 0.5 HR |
| Strikeouts | José Quintana Over 4.5 K |
| Total bases | Alec Burleson Over 1.5 TB |
Betting Trends & H2H
- The Brewers lead the season series against the Cardinals by a margin of 6-3.
- Milwaukee has won three straight games over the Cardinals heading into their meeting on Sunday.
Cardinals vs Brewers Model Projection
Score Projection: Cardinals 3 — Brewers 5
Win Probability: Cardinals 36% — Brewers 64%
Final Thoughts
Milwaukee’s edge shows up in several places. They have a superior record against right-handed pitching, enjoy quality home performance in afternoon starts, and a steadier bullpen behind a veteran starter who limits loud contact. Mikolas can keep this close if he avoids Milwaukee barrels, but his tendency to give up home runs makes him a tough fit in this setting against Yelich, Chourio and William Contreras. Brewers -1.5 is the best choice for bettors in this game.
