St. Louis Cardinals vs Milwaukee Brewers Pick – 9/12/2025
The St. Louis Cardinals and Milwaukee Brewers will face off in a matchup between two division foes on Friday night. The Brewers are in a great spot to win the NL Central and will try to move a step closer to doing that with a win tonight. They are taking on a desperate Cardinals team that is trying to stay within striking distance of the Wild Card leaders. Here, I take a closer look at this game and give you my Cardinals vs Brewers prediction for Friday.
Our Cardinals vs Brewers Pick
- Pick: Brewers -1.5
- Confidence: 4/5
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Game Snapshot
- Matchup: St. Louis Cardinals vs Milwaukee Brewers
- Date & Time: Saturday, September 13, 2025, 8:10 PM ET
- Starting Pitchers: Andre Pallante vs Quinn Priester
- Stadium: American Family Field, Milwaukee, WI
- Broadcast: MLB.TV
Key Storylines
- The Brewers are leading the race to finish the regular season with the best record in the league. They are two games ahead of the Philadelphia Phillies in that race and they are favored to move further ahead with a win in this game.
- St. Louis is four games back of the final National League Wild Card spot. They are running out of time to catch up to the teams ahead of them. But they are not going to give up and will try to pull closer with a win over a rival here.
Pitching matchup
The Cardinals are going to give the start to Andre Pallante in this contest. Pallante is 6-13 this season and has a 5.28 ERA. Pallante pitches to contact with just 104 strikeouts in 150 innings of work and the Brewers could make him pay with hard contact. Quinn Priester will get the start for Milwaukee tonight. Priester is an impressive 12-2 with a 3.25 ERA on the year.
Recent team streaks
- Both teams have lost three games in a row going into this matchup.
- The Cardinals were swept by the Seattle Mariners in their last series.
- The Brewers were swept by the Texas Rangers in their last series.
Best Player Props
| Player | Prop Type | Recommendation |
|---|---|---|
| Christian Yelich | Total Bases | Over 1.5 |
| William Contreras | Total Bases | Over 1.5 |
| Brice Turang | Total Bases | Over 1.5 |
Betting Trends & H2H
- The Brewers hold a 4-3 lead in the season series against the Cardinals.
- Milwaukee has won four of the last five games played between these teams.
- Milwaukee is 27-16 against division opponents this year.
- St. Louis is 20-20 against NL Central opponents.
Cardinals vs Brewers Model Projection
Score Projection: Cardinals 3 – Brewers 5
Win Probability: Cardinals 40%, Brewers 60%
Final Thoughts
The Milwaukee Brewers should continue their winning ways going into this matchup against the rival Cardinals. Milwaukee is 46-26 at home for the season and they have an elite starting pitcher throwing for them here. I’ll take the Brewers to win this game and cover the runline while dealing the Cardinals a crucial blow to their Wild Card hopes.
