St. Louis Cardinals vs Miami Marlins Pick – 8/20/2025

The final game of the three‑game series between the St. Louis Cardinals and Miami Marlins will take place on Wednesday at loanDepot Park. The Cardinals have taken the first two games of this series and will look to complete a sweep in this contest. Before the fun begins in South Florida, continue reading to get my Cardinals vs Marlins prediction for Wednesday night.

Our Cardinals vs Marlins Pick

  • Pick: Marlins Moneyline
  • Confidence: 2/5
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Game Snapshot

  • Matchup: St. Louis Cardinals vs Miami Marlins
  • Date & Time: Wednesday, August 20, 2025, 6:40 p.m. ET
  • Starting Pitchers: Sandy Alcántara (MIA) vs Andre Pallante (STL)
  • Stadium: loanDepot Park, Miami, FL
  • Broadcast: FDSFL and FDSMW

Key Storylines

Pitching matchup

Sandy Alcántara brings a 6‑11 record and a 6.31 ERA into tonight’s start. He is allowing over a hit per inning and has not looked like the pitcher that previously won the NL Cy Young award this year. Andre Pallante hasn’t been much better statistically and both of these men will look to string together a solid start to help their teams tonight.

Key Players

Ivan Herrera knocked in three runs for the Cardinals on Tuesday night and will look to make an impact again in this game. Miami’s Jakob Marsee had a triple and drove in a run on Tuesday. His continued impact has been a nice boost for Miami’s offense.

Recent team streaks

  • The Cardinals are trying to complete a series sweep after winning two straight games.
  • Miami has lost two games in a row and four of its last five heading into this contest.

Best Player Props

PlayerProp
Andre Pallante (STL)Under 4.5 Strikeouts
Ivan Herrera (STL)Over 1.5 Total Bases
Kyle Stowers (MIA)Over 1.5 Total Bases
  • The Cardinals lead the regular season series against the Marlins 3-2.
  • This is the final game scheduled between these teams during the 2025 MLB regular season.
  • The Cardinals are 28-34 on the road this season.
  • Miami is 28-33 in their home games on the year.

Cardinals vs Marlins Model Projection

Score Projection: Marlins 6 – Cardinals 5

Win Probability: Marlins 58.7 %, Cardinals 41.3 %

Final Thoughts

We should see a high-scoring game between these two teams thanks to the lack of trustworthy starting pitching on both sides. I think that Alcantara does have a higher upside than Pallante on the hill. But asking either of these pitchers to deliver over a lengthy start is a tough ask at this point. I’ll go with the Marlins as a slight favorite here and hope that Alcantara can reclaim his Cy Young form for a night.


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Home MLB Picks St. Louis Cardinals vs Miami Marlins Pick – 8/20/2025