St. Louis Cardinals vs Colorado Rockies Prediction – 7/23/2025

The St. Louis Cardinals close out their three‑game series in Denver against the struggling Colorado Rockies on Wednesday. The Cardinals are the favorites going into this matchup. But they have split the first two games of this series with the Rockies. Before this rubber match gets going from Colorado, continue reading to get my Cardinals vs Rockies prediction for today.

Our Cardinals vs Rockies Pick

• Pick: Cardinals moneyline
• Confidence: ★★★★☆
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Game Snapshot

• Matchup: St. Louis Cardinals @ Colorado Rockies
• Date & Time: Wednesday, July 23, 2025, 3:10 PM ET
• Starting Pitchers:
  • Cardinals – Andre Pallante (5–6, 4.71 ERA)
  • Rockies – TBA
• Stadium: Coors Field, Denver, CO
• Broadcast: COLR and FDSMW

Key Storylines

1. The Rockies have struggled all season, posting a 25–76 record and going 13–38 at home.
2. Andre Pallante’s been streaky this year for the Cardinals. But his team is 3–2 in his last five starts and he will look to give them the upper hand here as well.
3. St. Louis won the opener 6–2 and dropped Game 2 by a score of 8–4. They are 1-1 as favorites in this series thus far.
4. Colorado’s starter is yet to be announced. We could see them go with their bullpen for a full nine innings today. That would be troubling given that they 27th in the league in bullpen ERA.
5. The Cardinals have lost four of their last five games coming into this contest. Colorado snapped a two-game losing streak with a win over the Cardinals on Tuesday.

Best Player Props

Betting Trends & H2H

• The season series between these teams is tied 1-1.
• After this game, these teams will have another three-game series against each other in mid-August.
• The Cardinals are 24-24 in day games this season. The Rockies are 12-29 in day games.

Cardinals vs Rockies Model Projection

Score Projection: Cardinals 6 – Rockies 3

Win Probability: Cardinals 62% – Rockies 38%

Final Thoughts

St. Louis enters this game with clear advantage in pitching and run creation. Andre Pallante should be more stable than the Rockies bullpen in the early stages of this game. I think that Pallante will help the Cardinals get out to an early lead and that the St. Louis bullpen will do enough down the stretch to help Pallante get the win.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.