St. Louis Cardinals vs Colorado Rockies Prediction – 7/21/2025

The St. Louis Cardinals will look to halt a three-game skid when they head to Coors Field to face the Colorado Rockies on Monday night. The Cardinals are in the hunt for a Wild Card spot but they can’t afford to lose games against opponents like this one. Before these teams open up this three-game series, continue reading to get my Cardinals vs Rockies prediction.

Our Cardinals vs Rockies Pick

  • Pick: Cardinals -1.5
  • Confidence: 3 stars
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Game Snapshot

  • Matchup: St. Louis Cardinals vs Colorado Rockies
  • Date & Time: Monday, July 21, 2025, 8:40 p.m. ET
  • Starting Pitchers: Michael McGreevy vs Austin Gomber
  • Stadium: Coors Field, Denver, CO
  • Broadcast: COLR and FDSMW

Key Storylines

Pitching form

Michael McGreevy of the Cardinals has a 1-1 record and a 4.22 ERA this year. He has stepped into the rotation admirably after starting the year on spot duty. Colorado’s Austin Gomber has struggled with a 5.65 ERA and record of 0-3. He will look for his first win of the season in this game against a Cardinals team that is desperate for a win.

Bullpen usage

One of the biggest mismatches in this game is the bullpen quality of both sides. The Cardinals are in the top 10 in the league in bullpen ERA. Colorado is in the bottom half of the league in that category. That should give the Cards a decided advantage in this game.

Recent team streaks

The Cardinals have dropped three straight games. They were swept by the Arizona Diamondbacks in their last series. The Rockies have won two of their last three games. They won their series with the Minnesota Twins in surprising fashion over the weekend.

Best Player Props

PlayerProp
Hunter GoodmanHome runs (1+)
Michael McGreevyStrikeouts (Over 3.5)
Michael TogliaTotal bases (Over 1.5)
  • This is the first game of the season between the Cardinals and Rockies. These teams will play six games total during the regular season.
  • The Rockies are just 12-37 at home this year. St. Louis is 22-29 on the road and will look to take advantage of Colorado’s ineptitude at Coors Field.

Cardinals vs Rockies Model Projection

Score Projection: Cardinals 7 – Rockies 4

Win Probability: Cardinals 60%, Rockies 40%

Final Thoughts

I am going to lay the runline with the St. Louis Cardinals in this game. The Cards are struggling of late. But a trip to Coors Field could be exactly what they need to break out of their miniature slump. Expect a decent start from McGreevy and for the Cardinals to get a huge win for their Wild Card hopes.


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Home MLB Picks St. Louis Cardinals vs Colorado Rockies Prediction – 7/21/2025