St. Louis Cardinals vs Colorado Rockies Pick – 7/22/2025

The St. Louis Cardinals and Colorado Rockies continue their three-game series at Coors Field on Tuesday night. The Cardinals will be looking for a second straight win in the Mile High City after a 6–2 victory in the series opener. The Cards are favored going into this game against the team with the worst record in baseball. Keep reading to get my thoughts in this game and for my Cardinals vs Rockies prediction in the betting markets.

Our Cardinals vs Rockies Pick

• Pick: Cardinals -1.5
• Confidence: ★★★★☆
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4.8/5

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Game Snapshot

• Matchup: St. Louis Cardinals vs Colorado Rockies
• Date & Time: Tuesday, July 22, 2025, 8:40 PM EDT
• Starting Pitchers: Erick Fedde (STL) vs Bradley Blalock (COL)
• Stadium: Coors Field, Denver, CO
• Broadcast: COLR and FDSMW

Key Storylines

• Erick Fedde’s Performance: Fedde (3–9, 4.83 ERA) has struggled this season. But he faces a Rockies lineup that has been underperforming in this game. This could be just what he needs to get his ERA down and spark a turnaround in the second half of the season.
• Bradley Blalock’s Challenges: Blalock (0–2, 9.97 ERA) has had difficulty keeping runs off the board for the Rockies. In a hitter-friendly park tonight, that is likely to continue here.
• Bullpen Battle: The Cardinals are much better than the Rockies with their bullpen. Colorado’s pen ranks in the bottom five in the league this season. If this game comes down to relief pitching, I think the Cardinals have a decided edge.
• Rockies’ Offensive Woes: The Rockies have one of the lowest team batting averages in the league. That could hinder their ability to capitalize on scoring opportunities or their ability to even generate those opportunities.
• Let’s Go Streaking: The Cardinals are looking for their second straight win with a win tonight. The Rockies have dropped two games in a row and will aim to turn things around here.

Best Player Props

Betting Trends & H2H

• Both teams are 2-3 in their last five games.
• The Cardinals lead the season series 1-0 over the Rockies.
• With Monday’s loss, the Rockies dropped to 12-38 at home on the season. That is a win percentage of just 24% at home.

Cardinals vs Rockies Model Projection

• Score Projection: Cardinals 8 – Rockies 6
• Win Probability: Cardinals 54.7%, Rockies 45.3%

Final Thoughts

Both teams are sending struggling starting pitchers to the mound to open this game. But Fedde has at least shown the ability to be competitive this season. The same cannot be said for Blalock of the Rockies. And with Colorado having such a bad bullpen behind Blalock, I can’t see the Cardinals struggling to generate offense in this game. I’ll lay the runline with St. Louis on the road in this game.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.