St. Louis Cardinals vs Cincinnati Reds Prediction – 8/31/2025

The series between the St. Louis Cardinals and Cincinnati Reds will wrap up on Sunday in Cincinnati. The Cardinals are looking to secure a series sweep after back-to-back wins at Great American Ball Park. Cincinnati hands the ball to Brady Singer in an attempt to salvage a game from the series. Before the action begins between these NL Central rivals, continue reading to get my Cardinals vs Reds prediction for Sunday afternoon.

Our Cardinals vs Reds Pick

  • Pick: Cardinals moneyline
  • Confidence: 3/5
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Game Snapshot

  • Matchup: St. Louis Cardinals vs Cincinnati Reds
  • Date & Time: Sunday, August 31, 12:10 PM ET
  • Starting Pitchers: Andre Pallante vs Brady Singer
  • Stadium: Great American Ball Park, Cincinnati, OH
  • Broadcast: FDSOH, FDSMW

Key Storylines

Pitching Matchup

  • Brady Singer, CIN: Singer is 11-9 with a 4.06 ERA this season. His contact-heavy style means a lot of fly balls in a homer-friendly park and he will need to navigate the Cardinals lineup carefully.
  • Andre Pallante, STL: Pallante enters this start at 6-12 with a 5.44 ERA. He is an extreme ground-baller who depends on soft contact and defense. He can work efficiently through Cincinnati’s order if he keeps the ball down.

Key Players

  • Willson Contreras hit a home run for the Cardinals yesterday and will look to make another impact today.
  • Gavin Lux had an RBI double for the Reds on Saturday and will need to continue to produce to help the Reds end their losing streak.

Recent Team Streaks

  • The Cardinals have won three straight games. All of those wins came against NL Central opponents.
  • Cincinnati has lost five games in a row and eight of their last nine games.

Best Player Props

PlayerMarketPick
Elly De La CruzTotal BasesOver 1.5
Willson ContrerasHome RunsOver 0.5
Brady SingerStrikeoutsOver 4.5
Andre PallanteStrikeoutsUnder 4.5
  • The Cardinals hold a 6-3 lead in the season series against the Reds this year.
  • St. Louis has won four of their last five games against the Reds going into this contest.
  • St. Louis is 20-19 against NL Central opponents this year.
  • Cincinnati is 16-22 against division opponents in 2025.

Cardinals vs Reds Model Projection

Score Projection: Cardinals 5 – Reds 4

Win Probability: Cardinals 54% – Reds 46%

Final Thoughts

The Cincinnati Reds are better than the St. Louis Cardinals by a half-game in the NL Central standings going into Sunday’s game. But I think that the Cardinals will get a win and move ahead of the Reds after Sunday afternoon’s game. The Cardinals are playing well and the Reds are struggling mightily of late. Those trends should continue here and the Cardinals’ bats should once again do enough to get a win over the struggling Reds.


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Home MLB Picks St. Louis Cardinals vs Cincinnati Reds Prediction – 8/31/2025