St. Louis Cardinals vs Arizona Diamondbacks Prediction – 7/20/2025

The St. Louis Cardinals will face the Arizona Diamondbacks in the final game of their weekend series on Sunday afternoon. The Diamondbacks have used their offense to bludgeon the Cardinals through the first two games of this series. Arizona will look to complete a sweep at home with a win in this contest. Here, I will break down this National League contest and give you my Cardinals vs Diamondbacks prediction for this one.

Our Cardinals vs Diamondbacks Pick

• Pick: Diamondbacks -1.5
• Confidence: ★★★☆☆
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Game Snapshot

• Matchup: St. Louis Cardinals vs Arizona Diamondbacks
• Date & Time: Sunday, July 20, 2025 at 4:10 p.m. ET
• Starting Pitchers: Miles Mikolas vs Merrill Kelly
• Stadium: Chase Field, Phoenix, AZ
• Broadcast: TV ARID and FDSMW

Key Storylines

• Pitching form: Merrill Kelly has posted an 8-5 record and a 3.34 ERA. His 1.05 WHIP is a clear indicator that he is pitching well this year. St. Louis’ Miles Mikolas has struggled to a 5-6 record and a 4.94 ERA.
• Bullpen usage: The Diamondbacks has struggled for most of this season. But it has been the bullpen of the Cardinals that has had a hard time in this series so far. They have been lit up by the bats of the Diamondbacks and St. Louis will look to remedy that in this game.
• Recent team streaks: St. Louis has dropped two straight and four of its last five games. Arizona has won three games in a row entering this series finale from Phoenix.

Best Player Props

Betting Trends & H2H

• The Cardinals lead the season series between these teams by a 3-2 margin.
• The home team has won all five of the games between these teams in 2025.
• Arizona has outscored St. Louis 17-4 over the last two days.

Cardinals vs Diamondbacks Model Projection

• Score Projection: Diamondbacks 5 – Cardinals 3
• Win Probability: Diamondbacks 58%, Cardinals 42%

Final Thoughts

The Diamondbacks have had an edge over the Cardinals at home all series long. I don’t expect that edge to go away in this game. Merrill Kelly is pitching very well for the Diamondbacks and that should remain the case here. And with Mikolas struggling on the bump for the Cards, we could see another big day from Eugenio Suarez after his multi-homer game on Saturday. I’ll lay the runline with the Diamondbacks in this game.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.