St. Louis Cardinals vs Arizona Diamondbacks Prediction – 7/18/2025

The St. Louis Cardinals visit Chase Field to take on the Arizona Diamondbacks on Friday night. Both teams come into this game on the outside looking in in the NL Wild Card race. That makes this a very important game between two teams struggling to make their mark in 2025. Here, I break down this National League matchup and bring you my Cardinals vs Diamondbacks prediction from Phoenix.

Our Cardinals vs Diamondbacks Pick

• Pick: Diamondbacks moneyline
• Confidence: ★★★☆☆
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Game Snapshot

• Matchup: St. Louis Cardinals vs Arizona Diamondbacks
• Date & Time: Friday, July 18, 2025, 9:40 p.m. ET
• Starting Pitchers: Andre Pallante vs Brandon Pfaadt
• Stadium: Chase Field, Phoenix, AZ
• Broadcast: ARID and FDSMW

Key Storylines

1. Pitching form: Andre Pallante of the Cardinals has struggled with consistency this season. He is 5-5 with a 4.19 ERA and will look to get above the .500 mark with a win tonight. Arizona’s Brandon Pfaadt has alternated between strong outings and rough starts. He has a 9-6 record but a 5.16 ERA that suggests he is vulnerable to hard contact on any given night.
2. Bullpen usage: The Cardinals have the superior bullpen going into this game. Arizona is in the bottom five in bullpen ERA for the season. Both pens are rested following the All-Star break this past week.
3. Recent team streaks: Both clubs are 2-3 in their last five games. They both won their final game before the break and will look for a second straight victory tonight.

Best Player Props

Betting Trends & H2H

• The Cardinals lead the season series 3-0 after sweeping the Diamondbacks in St. Louis in May.
• The Cardinals are 27-24 in night games this year. Arizona is 30-32 at night in 2025.
• St. Louis is 22-26 on the road this season. The Diamondbacks are 23-25 in their home games.

Cardinals vs Diamondbacks Model Projection

Score Projection: Arizona 5 – St. Louis 4

Win Probability: Arizona 55%, St. Louis 45%

Final Thoughts

Consistency is a question mark for both teams and both starting pitchers in this game. But I think Pfaadt is a little better than his ERA would suggest. I’ll take the Diamondbacks to get the win at home here as they look to pull closer to the teams that currently occupy the three Wild Card spots in the National League.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.